Keratoprosthesis, and system and method of corneal repair using same

• US 9,974,646 B2
• Filed: 09/04/2013
• Issued: 05/22/2018
• Est. Priority Date: 09/05/2012
• Status: Active Grant

• Current Assignee: University of Miami
• Original Assignee: University of Miami
• Inventors: Parel, Jean-Marie, Sawatari, Yoh, Perez, Victor L., Bernal, Andres
• Primary Examiner(s): Willse, David H
• Assistant Examiner(s): SHIPMON, TIFFANY P
• Application Number:
  US14/426,195
• Publication Number:
  US 20150216651A1
• Time in Patent Office: 1,721 Days
• CPC Class Codes: A61F 2/142 Cornea, e.g. artificial corneae, keratoprostheses or corneal implants for repair of defective corneal tissue

Abstract

A keratoprosthesis and system and method of using same for corneal repair. The keratoprosthesis comprises a biocompatible support and an optic member disposed through a channel within the support. The support includes metal, preferably titanium, and treated, such as by sandblasting and/or acid etching, to create textured surfaces that promote soft tissue adhesion. A locking member interconnects the optic member and support. An outer surface of the locking member a collar extending from the support and disposed around the optic member is also metal, preferably titanium, and is similarly treated to promote soft tissue adhesion. A locking member interconnects the optic member and support. The system includes the keratoprosthesis positioned within an isolated soft tissue segment of a non-ocular tissue, such as buccal mucosa, placed on the anterior cornea. The method includes removing corneal epithelium, isolating and transplanting a segment of soft tissue to the de-epithelialized cornea, creating a receiving area in the soft tissue, positioning a keratoprosthesis relative to the receiving area anterior to the cornea, and securing the keratoprosthesis.

Claims

1. A keratoprosthesis comprising:

an optic member disposable in vision facilitating relation to an eye of a patient;

a biocompatible support having a channel disposed through said support, the channel defining a collar extending away from an anterior side of said biocompatible support;

said optic member disposed in said channel of said support such that the collar is disposed in at least partially surrounding relation to the optic member, said biocompatible support structured to be secured in place at a position anterior to a cornea of a patient'"'"'s eye and to engage soft tissue;

at least a portion of a surface of said biocompatible support including a treated surface structured to promote adhesion of soft tissue thereto, wherein said biocompatible support comprises a metallic material; and

wherein said collar and said biocompatible support comprise the same metallic material.

2. The keratoprosthesis as recited in claim 1, wherein said biocompatible support comprises titanium.

3. The keratoprosthesis as recited in claim 2 wherein said biocompatible support is made entirely of titanium.

4. The keratoprosthesis as recited in claim 2 wherein said biocompatible support comprises a core of at least one type of biocompatible material and at least one outer surface comprising titanium.

5. The keratoprosthesis as recited in claim 1 wherein said biocompatible support is disposable and securable in spaced relation to an anterior cornea.

6. The keratoprosthesis as recited in claim 1 wherein said biocompatible support is structured to engage a receiving area in soft tissue located anterior to the cornea.

7. The keratoprosthesis as recited in claim 1 wherein said biocompatible support comprises a diameter of approximately 10 millimeters.

8. The keratoprosthesis as recited in claim 1 wherein said biocompatible support comprises an elliptical shape.

9. The keratoprosthesis as recited in claim 1 wherein said biocompatible support comprises a plurality of apertures disposed along a periphery thereof to facilitate attachment of said biocompatible support.

10. The keratoprosthesis as recited in claim 9 wherein each of said plurality of apertures comprises a diameter of approximately 0.3 millimeters.

11. The keratoprosthesis as recited in claim 1 wherein said biocompatible support comprises a plurality of openings disposed throughout said biocompatible support in nutrient transmitting relation to the cornea.

12. The keratoprosthesis as recited in claim 11 wherein at least one of said plurality of openings comprise a contour to increase the surface area of said biocompatible support.

13. The keratoprosthesis as recited in claim 12 wherein at least one of said plurality of openings comprises a concave contour.

14. The keratoprosthesis as recited in claim 13 wherein at least one of said plurality of openings comprises a conical configuration.

15. The keratoprosthesis as recited in claim 1 wherein substantially all of an outer surface of said biocompatible support comprises a treated surface structured to promote adhesion of soft tissue thereto.

16. The keratoprosthesis as recited in claim 1 wherein said treated surface of said biocompatible support comprises a texture having microstructures ranging from generally about 0.5 to 2 microns in diameter.

17. The keratoprosthesis as recited in claim 1 wherein said surface is treated with at least one of sandblasting and acid etching to create enhanced soft tissue adhesion capabilities.

18. The keratoprosthesis as recited in claim 1 further comprising the collar disposed fully surrounding an outer wall of said optic member.

19. The keratoprosthesis as recited in claim 1 wherein said collar comprises at least one treated surface structured to promote adhesion of soft tissue thereto.

20. The keratoprosthesis as recited in claim 19 wherein said at least one treated surface of said collar comprises a texture having microstructures ranging from generally about 0.5 to 2 microns in diameter.

21. The keratoprosthesis as recited in claim 20 wherein said collar is treated with at least one of sandblasting and acid etching to create said texture of said at least one treated surface.

22. The keratoprosthesis as recited in claim 1 wherein said collar comprises a height of approximately 3 millimeters.

23. The keratoprosthesis as recited in claim 1 wherein said optic member comprises polymethylmethacrylate (PMMA).

24. The keratoprosthesis as recited in claim 1 wherein said optic member is secured within said channel of said biocompatible support.

25. The keratoprosthesis as recited in claim 1 further comprising a locking member structured and disposed in interconnecting securing relation between said optic member and said support.

26. The keratoprosthesis as recited in claim 25 wherein said locking member is disposed in at least partially encircling relation to said optic member.

27. The keratoprosthesis as recited in claim 26 wherein said locking member is disposed between said optic member and the collar extending from an anterior side of said biocompatible support.

28. The keratoprosthesis as recited in claim 25 wherein said locking member is secured to said optic member with methylethylketone (MEK).

29. The keratoprosthesis as recited in claim 25 wherein said locking member comprises polymethylmethacrylate (PMMA).