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Compositions comprising bacterial strains

  • US 9,974,815 B2
  • Filed: 11/03/2017
  • Issued: 05/22/2018
  • Est. Priority Date: 11/20/2015
  • Status: Active Grant
First Claim
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1. A method of treatment of cancer in a subject in need thereof, comprising:

  • administering to the subject a therapeutically effective amount of a pharmaceutical composition that comprises;

    a bacteria strain with a 16s rRNA gene sequence with at least 99.5% sequence identity to the polynucleotide of SEQ ID NO;

    2, wherein the sequence identity is determined by the Smith-Waterman homology search algorithm using an affine gap search with a gap open penalty of 12 and a gap extension penalty of 2, and a BLOSUM matrix of 62;

    wherein said bacteria strain has a carbohydrate fermentation profile that comprises;

    (i) a positive fermentation of at least one of;

    L-arabinose and D-xylose; and

    (ii) an intermediate fermentation of Methyl-α

    D-glycopyranoside;

    wherein said bacteria strain is present in an amount sufficient for treatment of cancer in the subject, and wherein the cancer is a solid tumor cancer.

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