Human placental collagen compositions, and methods of making and using the same
First Claim
1. A method of augmenting tissue repair in a subject comprising contacting said tissue with a composition comprising human placental extracellular matrix, wherein said human placental extracellular matrix comprises (i) placental collagen that comprises between 74% and 90% Type I collagen, between 4% to 6% Type III collagen, and between 2% to 15% type IV collagen (ii) no detectable amounts of fibronectin or laminin, and (iii) additional extracellular matrix components selected from the following groups:
- (a) 4.7% elastin by dry weight and 0.28% glycosaminoglycans by dry weight;
(b) 3.2% elastin by dry weight and 0.34% glycosaminoglycans by dry weight;
(c) 4.4% elastin by dry weight and 0.38% glycosaminoglycans by dry weight; and
(d) 3.5% elastin by dry weight and 0.59% glycosaminoglycans by dry weight.
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Abstract
The present invention provides compositions comprising human placental telopeptide collagen, methods of preparing the compositions, methods of their use and kits comprising the compositions. The compositions, kits and methods are useful, for example, for augmenting or replacing tissue of a mammal.
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Citations
12 Claims
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1. A method of augmenting tissue repair in a subject comprising contacting said tissue with a composition comprising human placental extracellular matrix, wherein said human placental extracellular matrix comprises (i) placental collagen that comprises between 74% and 90% Type I collagen, between 4% to 6% Type III collagen, and between 2% to 15% type IV collagen (ii) no detectable amounts of fibronectin or laminin, and (iii) additional extracellular matrix components selected from the following groups:
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(a) 4.7% elastin by dry weight and 0.28% glycosaminoglycans by dry weight; (b) 3.2% elastin by dry weight and 0.34% glycosaminoglycans by dry weight; (c) 4.4% elastin by dry weight and 0.38% glycosaminoglycans by dry weight; and (d) 3.5% elastin by dry weight and 0.59% glycosaminoglycans by dry weight. - View Dependent Claims (2, 3, 9, 10)
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4. A method of replacing tissue of a subject, comprising administering to the subject a composition comprising human placental extracellular matrix, wherein said human placental extracellular matrix comprises (i) placental collagen that comprises between 74% and 92% Type I collagen, 4% to 6% Type III collagen, and between 2% to 15% type IV collagen (ii) no detectable amounts of fibronectin or laminin, and (iii) additional extracellular matrix components selected from the following groups:
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(a) 4.7% elastin by dry weight and 0.28% glycosaminoglycans by dry weight; (b) 3.2% elastin by dry weight and 0.34% glycosaminoglycans by dry weight; (c) 4.4% elastin by dry weight and 0.38% glycosaminoglycans by dry weight; and (d) 3.5% elastin by dry weight and 0.59% glycosaminoglycans by dry weight. - View Dependent Claims (5, 6, 7, 8, 11, 12)
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Specification