Nanostructured gels capable of controlled release of entrapped agents
First Claim
1. A self-assembled gel composition controllably releasing an agent comprisinga gel composition prepared by self-assembly of a homogeneous solution of an enzyme cleavable amphiphilic gelator having a molecular weight of 2500 or less in a concentration of greater than 3 wt/vol % in one or more aqueous solvents containing an organic solvent in a concentration of between 0.5 and 75 vol/vol % of the total solvent volume, wherein the gelator meets the requirements of the FDA for Generally Recognized As Safe compounds;
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wherein the self-assembled gel composition comprises nanostructures comprising lamellar structures, fibers, sheet-like structures, tape-like structures, nanoparticles, or combinations thereof, each comprising the enzyme cleavable amphiphilic gelator;
wherein the one or more agents are at least partially encapsulated or entrapped by the nano structures, andwherein the agent is released from the gel composition in the presence of enzyme, andwherein the self-assembled gel is a viscous homogenous gel stable to inversion,optionally wherein solvent is removed from the gel composition by centrifugation, washing, lyophilization, drying, or combinations thereof.
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Abstract
Self-assembled gel compositions including a gelator, e.g., an enzyme-cleavable gelator, e.g., having a molecular weight of 2500 or less, are described. The self-assembled gel compositions can encapsulate one or more agents. Methods of making the self-assembled gel compositions, and methods of drug delivery using the self-assembled gel compositions are also described.
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Citations
33 Claims
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1. A self-assembled gel composition controllably releasing an agent comprising
a gel composition prepared by self-assembly of a homogeneous solution of an enzyme cleavable amphiphilic gelator having a molecular weight of 2500 or less in a concentration of greater than 3 wt/vol % in one or more aqueous solvents containing an organic solvent in a concentration of between 0.5 and 75 vol/vol % of the total solvent volume, wherein the gelator meets the requirements of the FDA for Generally Recognized As Safe compounds; - and
one or more agents for delivery from the gel composition; wherein the self-assembled gel composition comprises nanostructures comprising lamellar structures, fibers, sheet-like structures, tape-like structures, nanoparticles, or combinations thereof, each comprising the enzyme cleavable amphiphilic gelator; wherein the one or more agents are at least partially encapsulated or entrapped by the nano structures, and wherein the agent is released from the gel composition in the presence of enzyme, and wherein the self-assembled gel is a viscous homogenous gel stable to inversion, optionally wherein solvent is removed from the gel composition by centrifugation, washing, lyophilization, drying, or combinations thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 32)
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11. A self-assembled gel composition controllably releasing an agent comprising
a gel composition prepared by self-assembly of a homogeneous solution containing at least 3 wt/vol % of an enzyme cleavable amphiphilic gelator having a molecular weight of 2500 or less, a non-independent gelator, in one or more aqueous solvents containing an organic solvent in a concentration of between 0.5 and 75 vol/vol % of the total solvent volume, wherein the gelator meets the requirements of the FDA for Generally Recognized As Safe compounds; - and
one or more agents for delivery from the gel composition after exposure to enzyme under physiological conditions; wherein the enzyme cleavable amphiphilic gelator and the non-independent gelator in one or more aqueous solvents containing an organic solvent in a concentration of between 0.5 and 75 vol/vol % of the total solvent volume co-self-assemble into a viscous homogeneous gel, wherein the gel composition is stable to inversion and comprises nanostructures comprising lamellar structures, fibers, sheet-like structures, tape-like structures, nanoparticles, or combinations thereof, each comprising the enzyme cleavable amphiphilic gelator and the non-independent gelator; wherein the one or more agents are at least partially encapsulated or entrapped by the nano structures; and wherein solvent is removed from the gel composition by centrifugation, washing, lyophilization, drying, or combinations thereof. - View Dependent Claims (30, 31, 33)
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Specification