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Nanostructured gels capable of controlled release of entrapped agents

  • US 9,974,859 B2
  • Filed: 06/06/2016
  • Issued: 05/22/2018
  • Est. Priority Date: 09/24/2010
  • Status: Active Grant
First Claim
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1. A self-assembled gel composition controllably releasing an agent comprisinga gel composition prepared by self-assembly of a homogeneous solution of an enzyme cleavable amphiphilic gelator having a molecular weight of 2500 or less in a concentration of greater than 3 wt/vol % in one or more aqueous solvents containing an organic solvent in a concentration of between 0.5 and 75 vol/vol % of the total solvent volume, wherein the gelator meets the requirements of the FDA for Generally Recognized As Safe compounds;

  • andone or more agents for delivery from the gel composition;

    wherein the self-assembled gel composition comprises nanostructures comprising lamellar structures, fibers, sheet-like structures, tape-like structures, nanoparticles, or combinations thereof, each comprising the enzyme cleavable amphiphilic gelator;

    wherein the one or more agents are at least partially encapsulated or entrapped by the nano structures, andwherein the agent is released from the gel composition in the presence of enzyme, andwherein the self-assembled gel is a viscous homogenous gel stable to inversion,optionally wherein solvent is removed from the gel composition by centrifugation, washing, lyophilization, drying, or combinations thereof.

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