Apparatus for artificial cardiac simulation and method of using the same

• US 9,974,970 B2
• Filed: 10/13/2014
• Issued: 05/22/2018
• Est. Priority Date: 10/15/2013
• Status: Active Grant

• Current Assignee: Gloucestershire Hospitals NHS Foundation Trust (Government of United Kingdom)
• Original Assignee: Gloucestershire Hospitals NHS Foundation Trust (Government of United Kingdom)
• Inventors: Nuta, Bogdan, Lines, Ian
• Primary Examiner(s): Fairchild, Mallika D
• Application Number:
  US15/025,520
• Publication Number:
  US 20160235999A1
• Time in Patent Office: 1,317 Days
• CPC Class Codes: A61N 1/0563 specially adapted for defibrillation or cardioversion
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36842 Multi-site stimulation in the same chamber
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation
• CPC Class Codes: A61N 1/37288 Communication to several implantable medical devices within one patient
• CPC Class Codes: A61N 1/3756 Casings with electrodes thereon, e.g. leadless stimulators
• CPC Class Codes: A61N 1/3787 from an external energy source
• CPC Class Codes: A61N 1/39622 Pacing therapy
• CPC Class Codes: A61N 1/3987 characterised by the timing or triggering of the shock
• CPC Class Codes: A61N 2001/0585 Coronary sinus electrodes

Abstract

A system for artificial stimulation of the heart of a subject comprises a controller comprising a receiver for receiving signal data, a processor for processing received signal data, and a transmitter for transmitting signal data; a sensing stent for location in the proximal coronary sinus of the subject and comprising a sensing electrode assembly for sensing atrial and/or ventricular signals from the heart of the subject and a transmitter for transmitting signal data to the receiver; a stimulation stent for location in a vein of the subject distal of the sensing stent and comprising a receiver for receiving signal data from the transmitter and an electrode assembly for providing a stimulating electrical signal to the heart in response to the data received; and a defibrillator assembly for providing stimulation to the heart sufficient to defibrillate the heart in response to a signal received from the controller assembly.

Claims

1. A method for providing stimulation to a heart of a subject, the heart comprising a left atrium, a left ventricle, a right ventricle and a coronary sinus having an ostium, the method comprising:

sensing electrical activity of the heart at the ostium of the coronary sinus using a sensing stent implanted at the ostium of the coronary sinus, the sensing stent not being operable to provide pacing stimulation to the heart;

transmitting first signal data from a proximal region of the coronary sinus to a controller assembly;

generating second signal data for providing electrical stimulation to target tissue of the heart in response to the signal data received from the proximal region of the coronary sinus;

transmitting the second signal data to a stimulation stent for stimulation of target tissue;

providing electrical stimulation to the target tissue of the heart from the stimulation stent in response to the second signal data; and

in the case of a detected fibrillation of the heart, generating third signal data for providing electrical stimulation to the heart sufficient for defibrillation, transmitting the third signal data to a defibrillator assembly; and

providing electrical stimulation to the heart from the defibrillator assembly.

2. The method according to claim 1, wherein stimulation is provided to the left atrium and one or both ventricles.

3. The method according to claim 1, wherein defibrillation of the heart is effected using a coil disposed within the heart, wherein the coil is located at the coronary sinus.

4. The method according to claim 3, wherein defibrillation of the heart is effected by a first coil located at the coronary sinus and a second coil located distally of the coronary sinus.

5. The method according to claim 1, wherein the controller assembly is a subcutaneous or subpectoral implantable pulse generator.

6. The method according to claim 1, wherein the controller assembly comprises a battery, wherein the method further comprises charging the battery remotely by electrical induction.

7. The method according to claim 1, further comprising interrogating the controller assembly to determine operating parameters of pacing function of the controller assembly, and logging data received from the controller assembly and relating to function of the heart of the subject.

8. The method according to claim 1, further comprising powering the sensing stent remotely by electrical induction coupling, wherein the controller assembly comprises a coupling assembly, the coupling assembly coupling with the sensing stent and the sensing stent being powered by the controller assembly.

9. The method according to claim 1, wherein the sensing electrode assembly is comprised in a rigid assembly or a flexible assembly, the flexible assembly being movable between a retracted position and an expanded position.

10. The method according to claim 1, wherein the electrode assembly of the stimulation stent is comprised in a rigid assembly or a flexible assembly, the flexible assembly being movable between a retracted position and an expanded position.

11. The method according to claim 1, wherein pacing is provided to the left atrium of the subject.

12. The method according to claim 1, wherein stimulation is provided to the left ventricle of the subject at a plurality of sites.

13. The method according to claim 1 wherein stimulation is provided to the right ventricle of the subject.

14. The method according to claim 1, wherein the sensing stent comprises a defibrillator coil assembly.

15. The method according to claim 1, wherein the defibrillator assembly provides electrical power to the sensing stent and/or the stimulation stent by inductive coupling.