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Nucleic acids encoding modified FGF-21 polypeptides comprising non-naturally occurring amino acids

  • US 9,975,936 B2
  • Filed: 10/13/2016
  • Issued: 05/22/2018
  • Est. Priority Date: 03/30/2007
  • Status: Active Grant
First Claim
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1. An isolated nucleic acid that encodes a biologically active modified FGF-21 polypeptide comprising a non-naturally encoded amino acid, wherein:

  • (a) the modified FGF-21 polypeptide comprises a sequence at least 95% identical to SEQ ID NO;

    1 fused to an N-terminal methionine, SEQ ID NO;

    2, SEQ ID NO;

    3, SEQ ID NO;

    4, SEQ ID NO;

    5 fused to an N-terminal methionine, SEQ ID NO;

    6, or SEQ ID NO;

    7;

    (b) said non-naturally encoded amino acid has the structure;

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