Methods of scaling data used to construct biosensor algorithms as well as devices, apparatuses and systems incorporating the same
First Claim
1. A method of scaling amperometric data obtained during an electrochemical analysis of an analyte of interest to compensate for hematocrit and/or temperature, the method comprising the steps of:
- applying to a body fluid sample a test sequence comprising an AC block of low-amplitude signals and at least one DC block, wherein the body fluid sample comprises the analyte of interest;
measuring AC and DC current responses to an electro-active species indicative of the analyte of interest to obtain amperometric data; and
scaling the amperometric data from the measuring step by calculating admittance at from at least one of the AC current responses and then dividing the DC current responses by the admittance to obtain a compensated voltage that minimizes an influence of hematocrit and/or temperature on estimated analyte concentration.
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Abstract
Methods are disclosed for scaling body fluid analysis data to correct and/or compensate for confounding variables such as hematocrit (Hct), temperature, variations in electrode conductivity or combinations thereof before providing an analyte concentration. The scaling methods utilize current response data obtained from an AC block applied prior to a DC block to minimize the impact of such confounding variables upon the observed DC current response before creating descriptors or algorithms. The scaling methods therefore compensate the measured DC current by using data from the AC block made on the same sample. Also disclosed are devices, apparatuses and systems incorporating the various scaling methods.
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Citations
8 Claims
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1. A method of scaling amperometric data obtained during an electrochemical analysis of an analyte of interest to compensate for hematocrit and/or temperature, the method comprising the steps of:
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applying to a body fluid sample a test sequence comprising an AC block of low-amplitude signals and at least one DC block, wherein the body fluid sample comprises the analyte of interest; measuring AC and DC current responses to an electro-active species indicative of the analyte of interest to obtain amperometric data; and scaling the amperometric data from the measuring step by calculating admittance at from at least one of the AC current responses and then dividing the DC current responses by the admittance to obtain a compensated voltage that minimizes an influence of hematocrit and/or temperature on estimated analyte concentration. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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Specification