Systems and methods for on-site and real-time electrocardiographic imaging (ECGI)

• US 9,980,660 B2
• Filed: 01/07/2016
• Issued: 05/29/2018
• Est. Priority Date: 08/11/2008
• Status: Active Grant

• Current Assignee: Washington University In St Louis
• Original Assignee: Washington University In St Louis
• Inventors: Rudy, Yoram, Wang, Yong
• Primary Examiner(s): BOCKELMAN, MARK
• Application Number:
  US14/990,469
• Publication Number:
  US 20160113543A1
• Time in Patent Office: 873 Days
• CPC Class Codes: A61B 2018/00839 Bioelectrical parameters, e.g. ECG, EEG
• CPC Class Codes: A61B 5/0044 for the heart
• CPC Class Codes: A61B 5/282 Holders for multiple electrodes for introduction into the body A61B5/287
• CPC Class Codes: A61B 5/316 Modalities, i.e. specific diagnostic methods
• CPC Class Codes: A61B 5/6805 Vests
• CPC Class Codes: A61B 6/503 for diagnosis of the heart
• CPC Class Codes: A61B 6/5247 combining images from an ionising-radiation diagnostic technique and a non-ionising radiation diagnostic technique, e.g. X-ray and ultrasound
• CPC Class Codes: A61B 8/0883 for diagnosis of the heart
• CPC Class Codes: A61B 8/5261 combining images from different diagnostic modalities, e.g. ultrasound and X-ray

Abstract

A non-transitory computer readable medium stores instructions that, when executed by at least one processor, cause the at least one processor to perform a method that includes computing a transfer matrix representing a relative influence that each respective electrode location for measuring electrical potentials on a patient'"'"'s body has on an estimation of electrical potentials for locations on a surface of interest prior to the measuring of electrical potentials at the respective electrode locations and receiving electrical potential measurements measured via a plurality of electrodes at respective electrode locations on the patient'"'"'s body. The method also includes computing the estimation of electrical potentials for the locations on the surface of interest based at least in part on the received electrical potential measurements and the computed transfer matrix and generating image data representing the estimation of electrical potentials.

Claims

1. A non-transitory computer readable medium storing instructions that, when executed by at least one processor, cause the at least one processor to perform a method comprising:

computing a transfer matrix representing a relative influence that each respective electrode location for measuring electrical potentials on a patient'"'"'s body has on an estimation of electrical potentials for locations on a surface of interest of the patient'"'"'s body different than where the electrode locations are located, prior to the measuring of electrical potentials at the respective electrode locations;

receiving electrical potential data corresponding to measurements measured via a plurality of electrodes at the respective electrode locations on the patient'"'"'s body;

computing the estimation of electrical potentials for the locations on the body surface of interest based at least in part on the received electrical potential data and the computed transfer matrix; and

outputting, to a display device, an image of the body surface of interest that is indicative of the estimation of electrical potentials for the locations of the surface of interest.

2. The medium of claim 1, wherein the method further comprises:

receiving a user input to set a time period; and

the electrical potential data being accessed based on the time period such that the generated image represents the estimation of electrical potentials for the time period.

3. The medium of claim 1, wherein the processor computes the estimation of electrical potentials for the locations on the surface of interest and outputs the image substantially in real-time during a medical procedure to guide the medical procedure.

4. The medium of claim 1, wherein the method further comprises analyzing the estimation of electrical potentials for based on real-time electrical measurements during a medical procedure, such that the generated image provides real-time feedback of a result of the medical procedure.

5. The medium of claim 3, wherein the medical procedure is one of a catheter ablation and cardiac resynchronization therapy (CRT).

6. The medium of claim 1,

wherein computing the estimation comprises computing a plurality of transfer matrices prior to measuring the electrical potential on the patient'"'"'s body, the plurality of transfer matrices comprising a first transfer matrix and a second transfer matrix,

wherein the first transfer matrix represents a geometrical relationship between each of the electrode locations for measuring electrical potentials on the patient'"'"'s body and a plurality of locations on the surface of interest for which the estimation of electrical potentials are computed,

wherein the second transfer matrix represents a relative influence that each of the electrode locations for measuring electrical potentials on the patient'"'"'s body has on the estimation of electrical potentials for the locations on the surface of interest, and

wherein computing the estimation comprises multiplying the first transfer matrix and the electrical potential data to generate the estimation of electrical potentials for the locations on the surface of interest.

7. The medium of claim 6, wherein computing the estimation further comprises:

defining a simulated measurement of electrical potential measurements on the patient'"'"'s body;

computing a plurality of simulated estimations of electrical potentials on the surface of interest based on the simulated measurement and the first transfer matrix; and

generating the second transfer matrix from the computed plurality of simulated estimations.

8. The medium of claim 7, wherein computing the plurality of simulated estimations comprises computing the plurality of simulated estimations of electrical potentials using a linear regularization technique.

9. The medium of claim 1, wherein the surface of interest comprises a cardiac surface.

10. The medium of claim 9, wherein the cardiac surface comprises one of an epicardial surface and an endocardial surface.

11. The medium of claim 1, wherein computing the estimation comprises computing the estimation via a meshless Electrocardiographic Imaging (ECGI) technique.

12. A device, comprising:

a processor;

a non-transitory computer readable medium storing instructions that, when executed by the processor, cause the processor to;

compute a transfer matrix representing a relative influence that each of a plurality of electrode locations for measuring electrical potentials on a patient'"'"'s body has on an estimation of electrical potentials for locations on a surface of interest of the patient'"'"'s body different than where the electrode locations are located, the transfer matrix being computed prior to the measuring of electrical potentials at the respective electrode locations;

receive electrical potential measurements via a plurality of electrodes at respective electrode locations on the patient'"'"'s body;

compute the estimation of electrical potentials for the locations on the surface of interest based at least in part on the received electrical potential measurements and the computed transfer matrix; and

output, to a display device, an image of the body surface of interest that is indicative of the estimation of electrical potentials for the locations of the surface of interest.

13. The device of claim 12, further comprising a signal acquisition component comprising electrical inputs to receive the electrical potential measurements.

14. The device of claim 13, further comprising a plurality of electrodes connected to the electrical inputs and arranged to measure electrical potential at the plurality of electrode locations on the patient'"'"'s body.

15. The device of claim 12,

wherein the processor is further configured to compute a plurality of transfer matrices prior to receiving the electrical potential measurements, the plurality of transfer matrices comprising a first transfer matrix and a second transfer matrix,

wherein the first transfer matrix represents a geometrical relationship between each electrode location of the plurality of electrodes where the electrical potential measurements are measured and a plurality of locations on the surface of interest for which the estimation of electrical potentials are computed,

wherein the second transfer matrix represents a relative influence that each of the plurality of electrode locations for the electrical potentials measurements has on the estimation of electrical potentials for the locations on the surface of interest, and

wherein the processor is further configured to compute the estimation by multiplying the first transfer matrix and the electrical potential measurements.

16. The device of claim 15, wherein the processor is further configured to compute the estimation electrical potentials and to output the image substantially in real-time with respect to receiving the electrical potential measurements.

17. The device of claim 15, wherein the processor is further configured to:

define a simulated measurement of the electrical potential measurements;

compute a plurality of simulated estimations of electrical potentials on the surface of interest based on the simulated measurement and the first transfer matrix; and

generate the second transfer matrix from the plurality of simulated estimations.

18. A non-transitory computer readable medium storing machine executable instructions comprising:

a transfer matrix module that, when executed by at least one processor, causes the at least one processor to compute a transfer matrix representing a relative that each respective electrode location for measuring electrical potentials on a patient'"'"'s body has on an estimation of electrical potentials for locations on a surface of interest of the patient'"'"'s body different than where the electrode locations are located, prior to the measuring of electrical potentials at the respective electrode locations;

an acquisition module that, when executed by the at least one processor, causes the at least one processor to access measurement data corresponding to a plurality of electrical potentials measured via a plurality of electrodes at respective electrode locations on the patient'"'"'s body;

an estimation module that, when executed by the at least one processor, causes the at least one processor to compute the estimation of electrical potentials for the body surface of interest based at least in part on the measurement data and the computed transfer matrix; and

a display module that, when executed by the at least one processor, causes the at least one processor to output, to a display device, an image of the body surface of interest that is indicative of the estimation of electrical potentials for the locations on the surface of interest.

19. The medium of claim 18, wherein the processor computes the estimation of electrical potentials and generates the image data substantially in real-time in response to measuring electrical potentials at the respective electrode locations during a medical procedure.

20. The medium of claim 18, wherein the machine executable instructions further comprise a user interface to set a given time period for which the measurement data is accessed in response to a user input, such that the display module generates the image data based on the given time period.

21. A device, comprising:

a signal acquisition device comprising electrical inputs to receive electrical potential measurements;

a plurality of electrodes arranged to measure electrical potential at the plurality of electrode locations on a surface of the patient'"'"'s body, the electrodes connected to the electrical inputs to provide the electrical potential measurements;

a processor;

a non-transitory computer readable medium storing instructions that, when executed by the processor, cause the processor to;

compute a transfer matrix representing a relative influence that each of a plurality of electrode locations for measuring electrical potentials on a patient'"'"'s body has on an estimation of electrical potentials for locations on a surface of interest, which is different than the electrode locations on the surface of the patient'"'"'s body, the transfer matrix being computed prior to measuring of electrical potentials at the respective electrode locations;

compute the estimation of electrical potentials for the locations on the surface of interest based at least in part on the received electrical potential measurements and the computed transfer matrix; and

generating image data to display an output on a display device, the output comprising an image of the body surface of interest that is indicative of the estimation of electrical potentials for the locations on the surface of interest.