Electrocardiogram reconstruction from implanted device electrograms

• US 9,980,661 B2
• Filed: 05/24/2012
• Issued: 05/29/2018
• Est. Priority Date: 09/21/2007
• Status: Active Grant

• Current Assignee: University of Pittsburgh of The Commonwealth System of Higher Education
• Original Assignee: University of Pittsburgh of The Commonwealth System of Higher Education
• Inventors: Saba, Samir F., Williams, Jeffrey L., Mendenhall, George S.
• Primary Examiner(s): Patton, Amanda
• Application Number:
  US13/479,562
• Publication Number:
  US 20130317376A1
• Time in Patent Office: 2,196 Days
• Field of Search: 600509
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61B 5/363 Detecting tachycardia or bradycardia
• CPC Class Codes: A61B 5/686 Permanently implanted devices, e.g. pacemakers, other stimulators, biochips A61B5/6861 takes precedence

Abstract

A method of reconstruction of the standard 12-lead surface EKG given values of the electrical potential from an implanted medical device is described. This implanted device can be oriented in an arbitrary fashion and reconstruction technique is obtained through physical measurement of the orientation of the implanted device or correlation with a standard 12-lead EKG obtained from the patient.

Claims

1. A method, comprising:

a) providing;

i) a subject exhibiting symptoms of a cardiac disease, wherein said subject has an implanted cardiac device;

ii) a system comprising said implanted cardiac device and a microprocessor wherein said microprocessor comprises a plurality of reconstructed electrocardiogram (rEKG) threshold exceedances, wherein said microprocessor is capable of calculating a subject specific rEKG;

iii) a testing parameter known to detect said cardiac disease;

b) calculating said subject specific rEKG with said microprocessor while said testing parameter is administered to said subject; and

c) comparing said subject specific rEKG to said plurality of rEKG threshold exceedances with said microprocessor by analyzing or displaying said subject-specific rEKG such that said cardiac disease is diagnosed, and

d) signaling a warning with said implanted cardiac device about said diagnosed cardiac disease.

2. The method of claim 1, wherein said diagnosed cardiac disease comprises ischemia.

3. The method of claim 1, wherein said diagnosed cardiac disease comprises electrolyte abnormalities.

4. The method of claim 1, wherein said diagnosed cardiac disease comprises a myocardial infarction.

5. The method of claim 1, wherein said analyzing said rEKG comprises heart rhythm discrimination.

6. The method of claim 1, wherein said testing parameter comprises at least one medication.

7. The method of claim 1, wherein said testing parameter comprises a stress test.

8. The method of claim 1, wherein said testing parameter comprises a salt complex.

9. The method of claim 1, wherein said warning is in response to at least one of said plurality of threshold exceedances.

10. The method of claim 1, wherein said warning establishes said diagnosis of said cardiac disease.

11. The method of claim 1, wherein said warning is in regards to delivery of a medication.

12. The method of claim 1, wherein said warning is transmitted to a remote medical monitoring station.

13. The method of claim 1, wherein said warning is transmitted to an emergency frequency.

14. The method of claim 13, wherein said emergency frequency is a telephone 911 emergency frequency.