Methods and systems for renal neuromodulation
First Claim
1. A method of treating hypertension in a human patient having a systolic blood pressure at or above 140 mm Hg, the method comprising:
- inserting a mechanical device through vasculature of the human patient to a renal blood vessel;
pressing a distal portion of the mechanical device against an interior wall of the renal blood vessel, whereby the distal portion imparts mechanical force against the interior wall in a manner that at least partially disrupts function of renal neural fibers without delivery of electrical energy to the renal neural fibers,wherein disrupting function of the renal neural fibers results in a therapeutically beneficial decrease in blood pressure of the patient; and
removing the mechanical device from the renal blood vessel after pressing the device against the interior wall.
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Abstract
Methods for treating preventing or decreasing the likelihood of a human patient developing hypertension and associated systems and methods are disclosed herein. One aspect of the present technology, for example, is directed to methods for therapeutic renal neuromodulation that partially inhibit sympathetic neural activity in renal nerves proximate a renal blood vessel of a human patient. This reduction in sympathetic neural activity is expected to therapeutically treat one or more conditions associated with hypertension or prehypertension of the patient. Renal sympathetic nerve activity can be modulated, for example, using an intravascularly positioned catheter carrying a neuromodulation assembly, e.g., a neuromodulation assembly configured to use mechanically-induced, electro-magnetically-induced, and/or chemically-induced approaches to modulate the renal nerves.
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Citations
16 Claims
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1. A method of treating hypertension in a human patient having a systolic blood pressure at or above 140 mm Hg, the method comprising:
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inserting a mechanical device through vasculature of the human patient to a renal blood vessel; pressing a distal portion of the mechanical device against an interior wall of the renal blood vessel, whereby the distal portion imparts mechanical force against the interior wall in a manner that at least partially disrupts function of renal neural fibers without delivery of electrical energy to the renal neural fibers, wherein disrupting function of the renal neural fibers results in a therapeutically beneficial decrease in blood pressure of the patient; and removing the mechanical device from the renal blood vessel after pressing the device against the interior wall. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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Specification