Oxygen-enabled composition

• US 9,980,909 B2
• Filed: 04/21/2017
• Issued: 05/29/2018
• Est. Priority Date: 03/30/2016
• Status: Active Grant

• Current Assignee: Baylor University
• Original Assignee: Baylor University
• Inventors: Woodmansee, Jr., John W., Woodmansee, Robert A., Smith, James R.
• Primary Examiner(s): Shomer, Isaac
• Application Number:
  US15/493,688
• Publication Number:
  US 20170281544A1
• Time in Patent Office: 403 Days
• Field of Search: None
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61K 33/08 Oxides; Hydroxides
• CPC Class Codes: A61K 47/6949 inclusion complexes, e.g. clathrates, cavitates or fullerenes
• CPC Class Codes: A61K 9/0026 Blood substitute; Oxygen transporting formulations; Plasma extender
• CPC Class Codes: A61K 9/143 with inorganic compounds
• CPC Class Codes: A61K 9/1611 Inorganic compounds
• CPC Class Codes: C01F 7/02 Aluminium oxide; Aluminium hydroxide; Aluminates
• CPC Class Codes: C01F 7/023 Grinding, deagglomeration or disintegration
• CPC Class Codes: C01P 2004/60 Particles characterised by their size

Abstract

A composition of chlorine-free poly-oxygenated aluminum hydroxide that comprises a clathrate containing oxygen gas molecules. In one embodiment, the poly-oxygenated aluminum hydroxide has particles having a diameter of 212 microns or less. The composition may be homogeneous.

Claims

1. A composition, comprising:

a quantity of poly-oxygenated aluminum hydroxide comprising a clathrate containing oxygen gas molecules that is chlorine-free, wherein the poly-oxygenated aluminum hydroxide comprises particles each having a diameter of less than or equal to 212 μ

m.

2. The composition as specified in claim 1, wherein the poly-oxygenated aluminum hydroxide is homogeneous.

3. The composition as specified in claim 2, wherein the particles each have a diameter in the range of 107-212 um.

4. The composition as specified in claim 2, wherein the particles each have a diameter in the range of 46-106 um.

5. The composition as specified in claim 2, wherein the particles each have a diameter in the range of 26-45 um.

6. A quantity of poly-oxygenated aluminum hydroxide comprising a clathrate containing oxygen gas molecules that is chlorine-free, wherein the composition is not a desiccant.

7. A quantity of poly-oxygenated aluminum hydroxide comprising a clathrate containing oxygen gas molecules that is chlorine-free, wherein the poly-oxygenated aluminum hydroxide is configured to be intravenously delivered to a mammal.

8. A quantity of poly-oxygenated aluminum hydroxide comprising a clathrate containing oxygen gas molecules that is chlorine-free, wherein the poly-oxygenated aluminum hydroxide is configured to not create an immune response of a mammal.

9. The composition as specified in claim 8 wherein poly-oxygenated aluminum hydroxide is configured to be therapeutically effective in treating a condition of the mammal.

10. A quantity of poly-oxygenated aluminum hydroxide comprising a clathrate containing oxygen gas molecules that is chlorine-free, wherein the poly-oxygenated aluminum hydroxide is configured to deposit deep into a lung and perfuse out the lining of the lung.

11. A quantity of poly-oxygenated aluminum hydroxide comprising a clathrate containing oxygen gas molecules that is chlorine-free, wherein the poly-oxygenated aluminum hydroxide is configured to penetrate through epidermis and dermis layers of skin and reside in a subcutaneous layer of the skin.

12. A quantity of poly-oxygenated aluminum hydroxide comprising a clathrate containing oxygen gas molecules that is chlorine-free, wherein the poly-oxygenated aluminum hydroxide is configured to absorb through lining of an esophagus and a stomach.

13. A quantity of poly-oxygenated aluminum hydroxide comprising a clathrate containing oxygen gas molecules that is chlorine-free, wherein the poly-oxygenated aluminum hydroxide is configured to traverse a brood brain barrier (BBB) of a mammal.

14. A quantity of poly-oxygenated aluminum hydroxide comprising a clathrate containing oxygen gas molecules that is chlorine-free, wherein the poly-oxygenated aluminum hydroxide is configured to stay in a capillary, vein, or artery linings of a mammal circulatory system and not passively diffuse past a lining into surrounding tissue.

15. A composition, comprising:

a quantity of poly-oxygenated aluminum hydroxide comprising a clathrate containing oxygen gas molecules that is chlorine-free,

wherein the composition comprises particles each having a diameter of less than or equal to 212 μ

m; and

wherein the quantity of poly-oxygenated aluminum hydroxide is homogeneous.

16. The composition of claim 15, wherein the composition is made by a process that filters a quantity of a poly-oxygenated aluminum hydroxide.