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Thyroid hormone analogs and methods of use

  • US 9,980,933 B2
  • Filed: 08/26/2013
  • Issued: 05/29/2018
  • Est. Priority Date: 09/15/2003
  • Status: Active Grant
First Claim
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1. A method for treating a condition by promoting angiogenesis, wherein the condition is selected from the group consisting of occlusive vascular disease, coronary disease, erectile dysfunction, myocardial infarction, ischemia, stroke, peripheral artery vascular disorders, wound healing and burns, said method comprising the steps of:

  • formulating a polymer into a nanoparticle, wherein the nanoparticle is less than 200 nanometers, wherein the polymer is polyglycolide, polylactide, or a co-polymer thereof;

    conjugating a thyroid hormone analog to the nanoparticle forming a conjugated thyroid hormone analog;

    coating a medical device with the conjugated thyroid hormone analog;

    administering an effective amount of the conjugated thyroid hormone analog to a subject suffering from the condition by inserting the medical device coated with the conjugated thyroid hormone analog into the subject;

    initiating non-genomic signal transduction pathways at an integrin α



    3 surface receptor of a cell by contacting the conjugated thyroid hormone analog with the α



    3 surface receptor, said conjugated thyroid hormone analog does not gain entry to the cell'"'"'s interior.

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