Compositions and methods for inducing immune tolerance
First Claim
1. A method for suppressing or preventing an immune response to a specific antigen in a subject, comprising administering to the subject a pharmaceutical composition comprising a liposome composition displaying the antigen and a ligand for a sialic acid binding Ig-like lectin (Siglec).
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Abstract
The present invention provides liposomal compositions for inducing immune tolerance. The compounds typically comprise a liposome displaying a specific antigen and also a binding moiety for a sialic acid binding Ig-like lectin (Siglec) expressed on B cells. The invention also provides methods for inducing tolerance to a protein or polypeptide antigen (e.g., a protein antigen) in a subject. The methods involve administering to the subject a pharmaceutical composition thatco-presents both the antigen and a glycan ligand for a Siglec expressed on B lymphocytes.
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8 Claims
- 1. A method for suppressing or preventing an immune response to a specific antigen in a subject, comprising administering to the subject a pharmaceutical composition comprising a liposome composition displaying the antigen and a ligand for a sialic acid binding Ig-like lectin (Siglec).
Specification