Current sensing multiple output current stimulators

• US 9,981,130 B2
• Filed: 09/12/2016
• Issued: 05/29/2018
• Est. Priority Date: 03/15/2013
• Status: Active Grant

• Current Assignee: Alfred E. Mann Foundation For Scientific Research
• Original Assignee: Alfred E. Mann Foundation For Scientific Research
• Inventors: Lee, Edward K. F.
• Primary Examiner(s): Patton, Amanda
• Assistant Examiner(s): EDWARDS, PHILIP CHARLES
• Application Number:
  US15/263,046
• Publication Number:
  US 20160375246A1
• Time in Patent Office: 624 Days
• Field of Search: 607 34
• CPC Class Codes: A61N 1/36003 of motor muscles, e.g. for walking assistance
• CPC Class Codes: A61N 1/3605 Implantable neurostimulators for stimulating central or peripheral nerve system
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 1/36125 Details of circuitry or electric components
• CPC Class Codes: A61N 1/36146 specified by the stimulation parameters
• CPC Class Codes: H03K 3/012 Modifications of generator to improve response time or to decrease power consumption
• CPC Class Codes: H03K 3/023 by the use of differential amplifiers or comparators, with internal or external positive feedback

Abstract

A multiple output current stimulator circuit with fast turn on time is described. At least one pair of input side and output side transistors is arranged in a current mirror connected to a supply transistor by cascode coupling. The output side transistor supplies stimulation current to an electrode in contact with tissue. An operational amplifier connected to a reference voltage and to the output side transistor drives the supply transistor to maintain the voltage at the output side transistor equal to the reference voltage. The at least one pair of transistors includes multiple pairs of transistors whose output side transistors drive respective electrodes with stimulation currents. The stimulator determines the initiation and duration of stimulation current pulses supplied to each electrode. At circuit activation, large currents are generated which discharge capacitances in the output side transistors causing rapid output side transistor turn on.

Claims

1. An implantable neurostimulation system comprising:

a pulse generator comprising;

a multiple output current stimulator circuit comprising;

a current source;

a first resistor coupled to the current source to provide a reference voltage;

at least one output side transistor having a current output terminal for providing an output current;

a second resistor coupled between a voltage source and the at least one output side transistor to thereby provide a common sensing voltage; and

a differential amplifier comprising;

a first input coupled to the reference voltage;

a second input coupled to the common sensing voltage; and

an output arranged to drive the at least one output side transistor as a function of the difference between the reference voltage and the common sensing voltage.

2. The implantable neurostimulation system of claim 1, further comprising a lead connected to the pulse generator, wherein the lead comprises a plurality of conductive electrodes and a plurality of non-conductive regions.

3. The implantable neurostimulation system of claim 1, wherein the pulse generator comprises a plurality of electrical pulse programs.

4. The implantable neurostimulation system of claim 3, wherein the plurality of electrical pulse programs affect the frequency and strength of electrical pulses generated by the pulse generator.

5. The implantable neurostimulation system of claim 4 further comprising a controller that can communicate with the pulse generator to create one of the plurality of electrical pulse programs.

6. The implantable neurostimulation system of claim 4 further comprising a controller that can communicate with the pulse generator to select one of the plurality of electrical pulse programs.

7. The implantable neurostimulation system of claim 3 further comprising a first switch located between the output of the differential amplifier and the output side transistor, wherein the first switch is closed according to one of the plurality of electrical pulse programs.

8. The implantable neurostimulation system of claim 1, wherein current source is configured to generate a reference current.

9. The implantable neurostimulation system of claim 8, wherein the multiple output current stimulator circuit amplifies the reference current according to a ratio of resistances of the first resistor and the second resistor.

10. The implantable neurostimulation system of claim 9, further comprising a plurality of outputs in electrical connection with the second resistor.

11. The implantable neurostimulation system of claim 10, wherein a stimulator output current flowing through the second resistor is equal to a sum of current flowing through the outputs.

12. The implantable neurostimulation system of claim 11, wherein the first resistor comprises a plurality of resistors.

13. The implantable neurostimulation system of claim 11, wherein the second resistor comprises a plurality of resistors.

14. The implantable neurostimulation system of claim 11, wherein the multiple output current stimulator circuit has a turn on time of less than 5 us for an output current of less than 50 mA.

15. The implantable neurostimulation system of claim 14, wherein the turn on time is less than 2 us for an output current between 200 uA and 25 mA.

16. The implantable neurostimulation system of claim 15, wherein the turn on time is between 0.5 and 2 us for an output current between 200 uA and 25 mA.

17. The implantable neurostimulation system of claim 15, wherein the pulse generator is configured to generate at least one electrical pulse having a pulse width of 50 us.