Operation and estimation of output voltage of wireless stimulators

• US 9,981,138 B2
• Filed: 10/09/2012
• Issued: 05/29/2018
• Est. Priority Date: 03/25/2008
• Status: Active Grant

• Current Assignee: EBR Systems, Inc.
• Original Assignee: EBR Systems, Inc.
• Inventors: Willis, N. Parker
• Primary Examiner(s): Schaetzle, Kennedy
• Application Number:
  US13/648,027
• Publication Number:
  US 20130274828A1
• Time in Patent Office: 2,058 Days
• Field of Search: None
• CPC Class Codes: A61N 1/362 Heart stimulators heart defibrillators A61N1/39
• CPC Class Codes: A61N 1/37205 Microstimulators, e.g. implantable through a cannula
• CPC Class Codes: A61N 1/3756 Casings with electrodes thereon, e.g. leadless stimulators
• CPC Class Codes: A61N 1/3787 from an external energy source

Abstract

A controller-transmitter transmits acoustic energy through the body to an implanted acoustic receiver-stimulator. The receiver-stimulator converts the acoustic energy into electrical energy and delivers the electrical energy to tissue using an electrode assembly. The receiver-stimulator limits the output voltage delivered to the tissue to a predetermined maximum output voltage. In the presence of interfering acoustic energy sources output voltages are thereby limited prior to being delivered to the tissue. Furthermore, the controller-transmitter estimates the output voltage that is delivered to the tissue by the implanted receiver-stimulator. The controller-transmitter measures a query spike voltage resulting from the electrical energy delivered to the tissue by the receiver-stimulator, and computes a ratio of the predetermined maximum output voltage and a maximum query spike voltage. The maximum query spike voltage is computed by detecting a query spike voltage plateau. Based on this ratio, the controller-transmitter uses a measured query spike voltage to estimate the output voltage delivered by the receiver-stimulator to tissue.

Claims

1. An acoustic controller-transmitter device for transmitting acoustic energy into a body, comprising:

an output transducer assembly configured to transmit acoustic energy into the body, wherein the acoustic energy is received by an implantable acoustic receiver-stimulator configured to convert the acoustic energy into electrical energy and deliver the electrical energy to tissue;

a control circuitry configured to estimate an output voltage delivered to the tissue by the receiver-stimulator; and

a sensing electrode assembly, wherein the sensing electrode assembly is in contact with the body and is configured to detect and measure a query spike voltage as a result of the electrical energy delivered to the tissue by the receiver-stimulator.

2. The device of claim 1, wherein the controller-transmitter is configured to determine a maximum query spike voltage.

3. The device of claim 2, wherein the controller-transmitter determines the maximum query spike voltage by detecting and measuring a query spike voltage plateau.

4. The device of claim 2, wherein the controller-transmitter is configured to compute a ratio of the predetermined maximum output voltage and the maximum query spike voltage, and is further configured to estimate the output voltage of the receiver stimulator based on the ratio and on the query spike voltage.

5. The device of claim 1, wherein the controller-transmitter is configured to transmit sufficient acoustic energy to the receiver-stimulator to pace the tissue.

6. The device of claim 1, wherein the controller-transmitter is implantable in the body.

7. The device of claim 1, wherein the receiver-stimulator comprises a voltage limiter.

8. The device of claim 7, wherein the voltage limiter is configured to limit the output voltage delivered to the tissue to a predetermined maximum output voltage.

9. An implantable receiver-stimulator device for stimulating tissue in a body, comprising:

a transducer assembly configured to receive acoustic energy and convert the acoustic energy into electrical energy;

an electrode assembly configured to deliver the electrical energy to the tissue; and

a voltage limiter configured to limit the electrical voltage delivered to the tissue to a maximum electrical voltage limit;

wherein the voltage limiter is configured to limit the electrical voltage delivered to the tissue due to an interfering acoustic energy source to a level that does not stimulate tissue.

10. The device of claim 9, wherein the acoustic energy is transmitted by an external source through the body to the receiver-stimulator.

11. The device of claim 10, wherein the external source is a controller-transmitter.

12. The device of claim 11, wherein the controller-transmitter is implantable in the body.

13. The device of claim 9, wherein the receiver-stimulator is configured to transfer the electrical energy to the electrode assembly when the electrical energy converted from the acoustic energy produces a voltage that is less than or equal to the maximum electrical voltage limit as configured by the voltage limiter.

14. The device of claim 9, wherein the voltage limiter comprises a Zener diode.

15. The device of claim 9, wherein the voltage limiter comprises a series of forward biased diodes.

16. The device of claim 9, further comprising a low pass filter.

17. The device of claim 9, wherein the interfering acoustic energy source is a diagnostic ultrasound imaging device.

18. A system for stimulating tissue in a body, comprising:

an acoustic controller-transmitter configured to transmit acoustic energy into the body; and

an implantable acoustic receiver-stimulator configured to receive the acoustic energy and convert the acoustic energy into electrical energy, wherein the receiver-stimulator comprises an electrode assembly coupled to the tissue and configured to deliver the electrical energy to the tissue, and wherein the receiver-stimulator further comprises a voltage limiter configured to limit the electrical voltage delivered to the tissue;

wherein the controller-transmitter comprises a control circuitry configured to estimate an output voltage delivered to the tissue by the receiver-stimulator.

19. The system of claim 18, wherein the controller-transmitter is implantable in the body.

20. A method for stimulating tissue in a body, comprising:

transmitting acoustic energy from an acoustic energy source through the body to an acoustic receiver-stimulator;

converting the acoustic energy into electrical energy using the acoustic receiver stimulator;

delivering the electrical energy to the tissue using an electrode assembly; and

limiting the output voltage delivered to the tissue using a voltage limiter;

limiting the output voltage delivered to the tissue due to an interfering acoustic energy source to a level that does not stimulate tissue.

21. The method of claim 20, wherein the interfering acoustic energy source is a diagnostic ultrasound imaging device.