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Chiral control

  • US 9,982,257 B2
  • Filed: 07/12/2013
  • Issued: 05/29/2018
  • Est. Priority Date: 07/13/2012
  • Status: Active Grant
First Claim
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1. A chirally controlled oligonucleotide composition comprising a plurality of oligonucleotides of at least one type, wherein each type is defined by:

  • 1) base sequence;

    2) pattern of backbone linkages;

    3) pattern of backbone chiral centers; and

    4) pattern of backbone X-moieties (—

    X-L-R1);

    wherein;

    the oligonucleotides of the at least one type comprise one or more phosphorothioate triester internucleotidic linkages and one or more phosphate diester linkage;

    the oligonucleotides of the at least one type comprise at least two consecutive modified internucleotidic linkages; and

    oligonucleotides of the at least one oligonucleotide type comprise one or more modified internucleotidic linkages independently having the structure of formula (I);

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