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Asynchronous magnetic bead rotation (AMBR) microviscometer for analysis of analytes

  • US 9,983,110 B2
  • Filed: 11/04/2014
  • Issued: 05/29/2018
  • Est. Priority Date: 11/04/2013
  • Status: Active Grant
First Claim
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1. A method of detecting a chemical change in state of an analyte in a sample comprising:

  • (a) contacting the sample with a magnetic particle;

    (b) measuring a first instantaneous non-linear rotation rate of the magnetic particle in the sample at a first time; and

    (c) measuring a second instantaneous non-linear rotation rate of the magnetic particle in the sample at a second time;

    wherein a difference between the first instantaneous rotation rate relative to the second instantaneous rotation rate indicates a change in viscosity in the sample, which indicates the change in state of the analyte in the sample,wherein the chemical change in state is selected from the group consisting of nucleic acid synthesis, protein synthesis, nucleic acid hydrolysis, nucleic acid ligation, and protein hydrolysis.

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