Method and device for detection of bioavailable drug concentration
First Claim
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1. An electrochemical sensor comprising:
- at least one electrode and a coating that surrounds the electrode, the coating comprising a structural component, a water immiscible solvent, a resistance decreasing component, and an ion exchange component,wherein the coating selectively partitions an electrochemically active drug from a fluid or vapor sample whereby an electrochemical signal within the coating can be measured using the electrode;
wherein the coating comprises one or more of sodium tetrakis[3,5bis(trifluoromethyl) phenyl] borate (NaTFPhB) and potassium tetrakis[pentafluorophenyl] borate (KTPFPhB) as the ion exchange component; and
wherein the electrochemical sensor is a voltammetric sensor.
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Abstract
The present invention is directed to an electrochemical sensor involving an electrode and a coating that surrounds the electrode, the coating comprising a structural component, a water immiscible solvent, a resistance decreasing component, and an ion exchange component, wherein the coating selectively partitions an electrochemically active drug from a fluid or vapor sample whereby an electrochemical signal within the coating can be measured using the electrode. Devices and methods for using this electrochemical sensor are also disclosed.
31 Citations
13 Claims
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1. An electrochemical sensor comprising:
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at least one electrode and a coating that surrounds the electrode, the coating comprising a structural component, a water immiscible solvent, a resistance decreasing component, and an ion exchange component, wherein the coating selectively partitions an electrochemically active drug from a fluid or vapor sample whereby an electrochemical signal within the coating can be measured using the electrode; wherein the coating comprises one or more of sodium tetrakis[3,5bis(trifluoromethyl) phenyl] borate (NaTFPhB) and potassium tetrakis[pentafluorophenyl] borate (KTPFPhB) as the ion exchange component; and wherein the electrochemical sensor is a voltammetric sensor. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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Specification