Method and device for detection of bioavailable drug concentration
First Claim
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1. An electrochemical sensor comprising:
- at least one electrode and a coating that surrounds the electrode, the coating comprising a structural component, a water immiscible solvent, a resistance decreasing component, and an ion exchange component,wherein the coating selectively partitions an electrochemically active drug from a fluid or vapor sample whereby an electrochemical signal within the coating can be measured using the electrode;
wherein the coating comprises one or more of sodium tetrakis[3,5bis(trifluoromethyl) phenyl] borate (NaTFPhB) and potassium tetrakis[pentafluorophenyl] borate (KTPFPhB) as the ion exchange component; and
wherein the electrochemical sensor is a voltammetric sensor.
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Abstract
The present invention is directed to an electrochemical sensor involving an electrode and a coating that surrounds the electrode, the coating comprising a structural component, a water immiscible solvent, a resistance decreasing component, and an ion exchange component, wherein the coating selectively partitions an electrochemically active drug from a fluid or vapor sample whereby an electrochemical signal within the coating can be measured using the electrode. Devices and methods for using this electrochemical sensor are also disclosed.
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Citations
13 Claims
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1. An electrochemical sensor comprising:
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at least one electrode and a coating that surrounds the electrode, the coating comprising a structural component, a water immiscible solvent, a resistance decreasing component, and an ion exchange component, wherein the coating selectively partitions an electrochemically active drug from a fluid or vapor sample whereby an electrochemical signal within the coating can be measured using the electrode; wherein the coating comprises one or more of sodium tetrakis[3,5bis(trifluoromethyl) phenyl] borate (NaTFPhB) and potassium tetrakis[pentafluorophenyl] borate (KTPFPhB) as the ion exchange component; and wherein the electrochemical sensor is a voltammetric sensor. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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Specification