Multichannel potentiostat analyzer system and methods

• US 9,983,167 B2
• Filed: 10/30/2015
• Issued: 05/29/2018
• Est. Priority Date: 10/31/2014
• Status: Active Grant

• Current Assignee: Zansors LLC
• Original Assignee: Zansors LLC
• Inventors: Li, Baichen
• Primary Examiner(s): Le, Thang
• Assistant Examiner(s): Fortich, Alvaro
• Application Number:
  US14/928,617
• Publication Number:
  US 20160123921A1
• Time in Patent Office: 942 Days
• CPC Class Codes: G01N 27/416 Systems G01N27/27 takes precedence

Abstract

The present disclosure outlines a device having a multi-channel potentiostat circuit and a microcontroller for controlling the multi-channel potentiostat circuit. The multi-channel potentiostat circuit includes a counter electrode, a reference electrode, and a first switch between the counter electrode and the reference electrode. The multi-channel potentiostat circuit also includes a plurality of measurement circuits coupled to respective second switches. The microcontroller can configured to provide a first signal to the multi-channel potentiostat circuit to control the first switch, wherein a state of the first switch changes an operating mode of the multi-channel potentiostat circuit. The microcontroller is also configured to provide a second signal to the multi-channel potentiostat circuit to control at least one of the second switches to couple at least one of the plurality of measurement circuits to a working electrode.

Claims

1. A device comprising:

a multi-channel potentiostat circuit comprising;

a counter electrode and a reference electrode,

a stabilizing switch configured to switch between electrically coupling the counter electrode to the reference electrode and electrically isolating the counter electrode from the reference electrode,

a first interference switch of a plurality of interference switches configured to switch between electrically coupling a first measurement circuit of a plurality of measurement circuits to a corresponding first working electrode of a plurality of working electrodes, and electrically isolating the first measurement circuit from the corresponding first working electrode, and

a second interference switch of the plurality of interference switches configured to switch between electrically coupling a second measurement circuit of the plurality of measurement circuits to a corresponding second working electrode of the plurality of working electrodes, and electrically isolating the second measurement circuit from the corresponding second working electrode; and

a microcontroller configured to;

provide a first signal to the multi-channel potentiostat circuit to control the stabilizing switch, wherein a state of the stabilizing switch changes an operating mode of the multi-channel potentiostat circuit, and

provide a second signal to the multi-channel potentiostat circuit to control at least one of the plurality of interference switches to couple at least one of the plurality of measurement circuits to its corresponding working electrode of the plurality of working electrodes,

wherein measurements on each of the plurality of working electrodes are produced with respect to the counter electrode and/or the reference electrode.

2. The device of claim 1, wherein the first signal indicates whether the multi-channel potentiostat circuit operates in a 2-lead operating mode or in a 3-lead operating mode.

3. The device of claim 2, wherein the multi-channel potentiostat circuit operates in the 2-lead operating mode when the stabilizing switch is closed and the multi-channel potentiostat circuit operates in the 3-lead operating mode when the stabilizing switch is open.

4. The device of claim 1, further comprising a gain amplifier configured to amplify one or more outputs of the multi-channel potentiostat circuit and to provide an amplified output to the microcontroller.

5. The device of claim 1, wherein a default state of the stabilizing switch is closed to prevent a floating voltage.

6. The device of claim 1, wherein the microcontroller is configured to sequentially close each of the plurality of interference switches to couple each of the plurality of measurement circuits to its corresponding working electrode of the plurality of working electrodes one-by-one.

7. The device of claim 1, wherein the second signal comprises two or more control signals configured to simultaneously close corresponding two or more of the plurality of interference signals switches to couple respective working electrodes of the plurality of working electrodes to their corresponding measurement circuits of the plurality of measurement circuits when the corresponding measurement circuits of the plurality of measurement circuits share a same voltage bias or a same voltammetry function.

8. The device of claim 1, wherein the device is powered using a connection to a computing device via a universal serial bus (“

USB”

) connection.

9. A multi-channel potentiostat circuit comprising:

a counter electrode and a reference electrode;

a stabilizing switch configured to switch between electrically coupling the counter electrode to the reference electrode and electrically isolating the counter electrode from the reference electrode;

a first interference switch of a plurality of interference switches configured to switch between electrically coupling a first measurement circuit of a plurality of measurement circuits to a corresponding first working electrode of a plurality of working electrodes, and electrically isolating the first measurement circuit from the corresponding first working electrode; and

a second interference switch of the plurality of interference switches configured to switch between electrically coupling a second measurement circuit of the plurality of measurement circuits to a corresponding second working electrode of the plurality of working electrodes, and electrically isolating the second measurement circuit from the corresponding second working electrode,

wherein measurements on each of the plurality of working electrodes are produced with respect to the counter electrode and/or the reference electrode.

10. The multi-channel potentiostat circuit of claim 9, wherein the multi-channel potentiostat circuit is configured to operate in a first operating mode or a second operating mode based on a control signal.

11. The multi-channel potentiostat circuit of claim 10, wherein the first operating mode is a 2-lead operating mode and the second operating mode is a 3-lead operating mode.

12. The multi-channel potentiostat circuit of claim 11, wherein the multi-channel potentiostat circuit operates in the 2-lead operating mode when the stabilizing switch is closed and the multi-channel potentiostat circuit operates in the 3-lead operating mode when the stabilizing switch is open.

13. The multi-channel potentiostat circuit of claim 9, wherein each of the plurality of interference switches are configured to be sequentially closed to couple each of the plurality of measurement circuits to its corresponding working electrode of the plurality of working electrodes one-by-one.

14. The multi-channel potentiostat circuit of claim 9, wherein two or more of the plurality of interference switches are configured to be closed simultaneously to couple respective working electrodes of the plurality of working electrodes to their corresponding measurement circuits of the plurality of measurement circuits when the corresponding measurement circuits of the plurality of measurement circuits share a same voltage bias or a same voltammetry function.

15. The multi-channel potentiostat circuit of claim 9, wherein a default state of the stabilizing switch is closed to prevent a floating voltage.

16. A method for operating a multi-channel potentiostat circuit comprising:

providing a first signal to the multi-channel potentiostat circuit to control an operating mode of the multi-channel potentiostat circuit by switching a stabilizing switch between electrically coupling a counter electrode to a reference electrode and electrically isolating the counter electrode from the reference electrode; and

providing a second signal to the multi-channel potentiostat circuit to control at least a first interference switch of a plurality of interference switches, the first interference switch configured to switch between electrically coupling a first measurement circuit of a plurality of measurement circuits of the multi-channel potentiostat circuit to a corresponding first working electrode of a plurality of working electrodes, and electrically isolating the first measurement circuit from the corresponding first working electrode,

wherein the plurality of interference switches comprise a second interference switch configured to switch between electrically coupling a second measurement circuit of the plurality of measurement circuits to a corresponding second working electrode of the plurality of working electrodes, and electrically isolating the second measurement circuit from the corresponding second working electrode, and wherein measurements on each of the plurality of working electrodes are produced with respect to the counter electrode and/or the reference electrode.

17. The method of claim 16, wherein the operating mode comprises a 2-lead operating mode and a 3-lead operating mode, and wherein the multi-channel potentiostat circuit operates in the 2-lead operating mode when the first signal causes the stabilizing switch to close and the multi-channel potentiostat circuit operates in the 3-lead operating mode when the first signal causes the stabilizing switch to open.

18. The method of claim 17, wherein a default state of the stabilizing switch is closed to prevent a floating voltage.

19. The method of claim 17, wherein, when operating in the 3-lead operating mode, the second signal comprises a plurality of control signals, and the method further comprises sequentially closing each of the plurality of interference switches specified by the plurality of control signals to couple each of the plurality of measurement circuits to its corresponding working electrode of the plurality of working electrodes one-by-one.

20. The method of claim 17, wherein, when operating in the 3-lead operating mode, the second signal comprises a plurality of control signals, and wherein the method further comprises simultaneously closing two or more of the plurality of interference switches specified by the plurality of control signals to couple respective working electrodes of the plurality of working electrodes to their corresponding measurement circuits of the plurality of measurement circuits when the corresponding measurement circuits of the plurality of measurement circuits share a same voltage bias or a same voltammetry function.