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In vitro method for the early detection of a potential inflammation, in particular associated with rejection of a transplant, a neurodegenerative disorder or a depression

  • US 9,983,212 B2
  • Filed: 05/02/2014
  • Issued: 05/29/2018
  • Est. Priority Date: 05/03/2013
  • Status: Active Grant
First Claim
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1. A method for the early detection of a potential inflammation in a patient caused by a rejection of a transplant before any clinical symptoms occur, comprising:

  • obtaining a saliva sample from the patient after receiving a transplant but prior to the patient recognizing any clinical symptoms of a transplant rejection;

    measuring the level of one or more kynurenine metabolites selected from the group consisting of L-kynurenine, kynurenic acid, 3-hydroxy-L-kynurenine and combinations thereof in the saliva sample by a competitive assay utilizing kynurenine-specific antibodies;

    diagnosing the patient with a transplant rejection when said kynurenine level in the saliva sample of the patient is from about 2 μ

    M/L to about 7 μ

    M/L; and

    administering immunosuppressive graft-saving therapy to the diagnosed patient.

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