Biopsy cavity marking device

• US 9,986,974 B2
• Filed: 10/08/2004
• Issued: 06/05/2018
• Est. Priority Date: 12/24/1998
• Status: Expired due to Fees

• Current Assignee: Devicor Medical Products Incorporated (Danaher Corporation)
• Original Assignee: Devicor Medical Products Incorporated (Danaher Corporation)
• Inventors: Sirimanne, D. Laksen, Sutton, Douglas S., Fawzi, Natalie V., Lebovic, Gail
• Primary Examiner(s): Cattungal, Sanjay
• Application Number:
  US10/961,979
• Publication Number:
  US 20050080339A1
• Time in Patent Office: 4,988 Days
• Field of Search: 600 2- 4, 600 7, 600 266, 600 36, 600407-480, 604 53, 604265, 424423, 424426, 606130, 606194, 606196, 623 1, 623 11, 623 12, 128408, 602 1- 3
• CPC Class Codes: A61B 2090/3908 Soft tissue, e.g. breast tissue
• CPC Class Codes: A61B 2090/3987 Applicators for implanting markers
• CPC Class Codes: A61B 8/481 involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream analysis of echo signal exploiting properties of a contrast enhancer in devices for short-range imaging with acoustic waves G01S7/52039
• CPC Class Codes: A61B 90/39 Markers, e.g. radio-opaque or breast lesions markers
• CPC Class Codes: A61K 49/006 Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
• CPC Class Codes: A61K 49/222 characterised by a special physical form, e.g. emulsions, liposomes

Abstract

These are site marking devices for marking a selected site within tissue of a patient. More particularly, the devices include an elongated body of gel and a metallic band disposed at least partially surrounding the body of gel. The body of gel is recognizably artificial when the marker is subject to ultrasound or x-ray imaging. Therefore, it is readily distinguishable from biological features within the tissue site.

Claims

1. A biopsy marker for marking a selected biopsy site within tissue of a patient, comprising:

a) a body of expandable, bioabsorbable material, the body defining a first closed volume prior to deployment within the biopsy site, and the body defining a second, larger generally closed volume after being placed within the biopsy site, and wherein the body has a generally continuous outer surface enclosing the volume; and

b) a radiopaque marker carried by the body, wherein the radiopaque marker is recognizably artificial when the marker is subject to ultrasound or X-ray imaging, so as to be readily distinguishable from biological features within the biopsy site; and

wherein the body is expandable relative to the radiopaque marker.

2. The biopsy marker of claim 1 wherein the body comprises collagen.

3. The biopsy marker of claim 1 wherein the body comprises a matrix.

4. The biopsy marker of claim 3 wherein the body comprises a collagen-fibrin matrix.

5. The biopsy marker of claim 1 wherein the body comprises a synthetic polymer.

6. The biopsy marker of claim 1 wherein the body comprises PGA.

7. The biopsy marker of claim 1 wherein the body comprises PLA.

8. The biopsy marker of claim 1 wherein the body comprises a gel.

9. The biopsy marker of claim 1 wherein the body comprises a block copolymer.

10. The biopsy marker of claim 1 wherein the body comprises a random copolymer.

11. The biopsy marker of claim 1 wherein the body comprises a number of pores through which tissue may grow.

12. The biopsy marker of claim 1 wherein the body comprises an outer shell.

13. The biopsy marker of claim 1 wherein the radiopaque marker is disposed about at least a portion of the outer surface of the body.

14. The biopsy marker of claim 1 wherein the radiopaque marker comprises a metallic marker.

15. The biopsy marker of claim 1 wherein the body has a first shape prior to deployment into the biopsy site, and a second shape different from the first shape after being deployed into the biopsy site.

16. The biopsy marker of claim 1 wherein the radiopaque marker does not expand and does not change shape upon being deployed into the biopsy site.

17. The biopsy marker of claim 1 wherein the body comprises a plurality of pores traversing the thickness of the body.

18. The biopsy marker of claim 1 wherein the body comprises a plurality of randomly oriented pores traversing the thickness of the body.

19. The biopsy marker of claim 1 wherein the body includes hemostatis-promoting agent.

20. The biopsy marker of claim 1, wherein the radiopaque marker includes a metallic marker having a helical coil shape.