Temporarily stiffened mesh prostheses

• US 9,987,116 B2
• Filed: 07/26/2016
• Issued: 06/05/2018
• Est. Priority Date: 02/08/2006
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: TYRX, INC. (Medtronic Plc)
• Inventors: Buevich, Fatima, Do, Frank, McJames, William, Pulapura, Satish, Edelman, William, Moses, Arikha, Diamond, Mason, Timothy, Shari
• Primary Examiner(s): Tran, Susan T
• Assistant Examiner(s): Craigo, William
• Application Number:
  US15/219,780
• Publication Number:
  US 20160331505A1
• Time in Patent Office: 679 Days
• Field of Search: None
• CPC Class Codes: A61F 2/0063 Implantable repair or support meshes, e.g. hernia meshes
• CPC Class Codes: A61F 2210/0004 bioabsorbable
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61F 2310/0097 Coating or prosthesis-covering structure made of pharmaceutical products, e.g. antibiotics
• CPC Class Codes: A61L 2300/402 Anaestetics, analgesics, e.g. lidocaine
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/406 Antibiotics
• CPC Class Codes: A61L 2300/416 Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
• CPC Class Codes: A61L 2300/45 Mixtures of two or more drugs, e.g. synergistic mixtures
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 2430/02 for reconstruction of bones; weight-bearing implants
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/146 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61P 23/02 Local anaesthetics
• CPC Class Codes: A61P 31/00 : Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Abstract

The present invention relates to medical prostheses and methods of manufacturing those devices. In particular, the prostheses are temporarily stiffened meshes with particular coatings to provide initial stiffness and thereby permit easier surgical handling for treatment or reconstruction of soft tissue defects. Preferred embodiments include surgical meshes coated with one or more biodegradable polymers that can act as a stiffening agent by coating the filaments or fibers of the mesh to temporarily immobilize the contact points of those filaments or fibers and/or by increasing the stiffness of the mesh by at least 1.1 times its original stiffness. The devices of the invention can also provide relief from various post-operative complications associated with their implantation, insertion or surgical use. By including biologically active agents and/or drugs in the coating, the devices provide prophylaxis for and can alleviate side effects or complications associated with the surgery or use of prostheses in general.

Claims

1. A medical prosthesis comprising a porous surgical mesh with a polymer coating, wherein the polymer coating is applied to the mesh without substantially altering a porosity of the surgical mesh, and wherein the polymer coating comprises a tyrosine-derived polyarylate.

2. A medical prosthesis as recited in claim 1, wherein the polymer coating is biodegradable.

3. A medical prosthesis as recited in claim 1, wherein the polymer coating is resorbable.

4. A medical prosthesis as recited in claim 1, wherein the medical prostheses is configured for orthopaedic graft support or stabilization.

5. A medical prosthesis as recited in claim 1, wherein the polymer coating comprises one or a plurality of coatings.

6. A medical prosthesis as recited in claim 1, wherein the tyrosine-derived polyarylate is from the P22-xx family.

7. A medical prosthesis as recited in claim 6, wherein the tyrosine-derived polyarylate from the P22-xx family is P22-27.5.

8. A medical prosthesis comprising a porous surgical mesh with a polymer coating, wherein the polymer coating is applied to the mesh without substantially altering a porosity of the surgical mesh, and wherein the polymer coating comprises a tyrosine-derived polyarylate and an antimicrobial agent.

9. A medical prosthesis as recited in claim 8, wherein the antimicrobial agent comprises at least one of rifampin and minocycline.

10. A medical prosthesis as recited in claim 8, wherein the polymer coating is biodegradable.

11. A medical prosthesis as recited in claim 8, wherein the polymer coating is resorbable.

12. A medical prosthesis as recited in claim 8, wherein the medical prostheses is configured for orthopaedic graft support or stabilization.

13. A medical prosthesis as recited in claim 8, wherein the tyrosine-derived polyarylate is from the P22-xx family.

14. A medical prosthesis as recited in claim 13, wherein the tyrosine-derived polyarylate from the P22-xx family is P22-27.5.

15. A medical prosthesis comprising a porous surgical mesh with a polymer coating, wherein the polymer coating is applied to the mesh without substantially altering a porosity of the surgical mesh, and wherein the polymer coating comprises chitosan and a tyrosine-derived polyarylate.

16. A medical prosthesis as recited in claim 15, wherein the polymer coating comprises an antimicrobial agent.

17. A medical prosthesis as recited in claim 16, wherein the antimicrobial agent comprises at least one of rifampin and minocycline.

18. A medical prosthesis as recited in claim 15, wherein the tyrosine-derived polyarylate is from the P22-xx family.

19. A medical prosthesis as recited in claim 18, wherein the tyrosine-derived polyarylate from the P22-xx family is P22-27.5.

20. A medical prosthesis as recited in claim 15, wherein the polymer coating is biodegradable.