Device for dispensing intraocular substances

• US 9,987,163 B2
• Filed: 04/16/2014
• Issued: 06/05/2018
• Est. Priority Date: 04/16/2013
• Status: Active Grant

• Current Assignee: Alcon Incorporated
• Original Assignee: Novartis Ag
• Inventors: Schaller, Michael
• Primary Examiner(s): Scherbel, Todd J
• Assistant Examiner(s): Sass, Sara
• Application Number:
  US14/254,366
• Publication Number:
  US 20140309599A1
• Time in Patent Office: 1,511 Days
• CPC Class Codes: A61F 9/0008 Introducing ophthalmic products into the ocular cavity or retaining products therein putting in contact lenses A61F9/0061; introducing or retaining media in cavities of the body in general A61M31/00
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: A61M 2005/2407 from the rear
• CPC Class Codes: A61M 2005/3143 Damping means for syringe components executing relative movements, e.g. retarders or attenuators slowing down or timing syringe mechanisms
• CPC Class Codes: A61M 5/31526 by means of stepwise axial movements, e.g. ratchet mechanisms or detents

Abstract

This disclosure relates generally to an injection device having a plunger configured to advance a distance into a container of material, such as a viscoelastic container; a trigger mechanism configured upon an actuation of the trigger mechanism to apply a first force to a spring element; and the spring element coupled to the plunger and configured to apply a second force to the plunger and which is configured to prevent exceeding a threshold maximum force applied to the container.

Claims

1. An ophthalmic injection device, comprising:

a pistol-shaped housing having a grip handle and an elongated slot formed by straight edges formed on and extending through an outer side wall of the housing such that the slot is on an outer surface of the injection device;

a plunger mechanically coupled to the housing and configured to advance a distance into a container holding a material;

a pushing mechanism coupled to the housing and configured, upon an actuation of the pushing mechanism of a distance, to apply a force to a spring element, wherein the pushing mechanism comprises a trigger handle that pivots toward the grip handle when actuated; and

the spring element contained entirely within the housing and configured to apply the force to the plunger and configured to dampen the distance moved by the pushing mechanism from the distance moved by the plunger; and

the container,

wherein the container is a cylindrical body that fits into the slot of the housing, wherein the container inserts into the slot on the outer side wall of the housing and wherein the container has a blunt distal end; and

a small delivery lumen configured to communicate with the container, wherein the small delivery lumen has an outlet configured to be placed within a structure of an eye.

2. The device in claim 1, wherein the spring element prevents the force applied to the plunger from reaching a threshold maximum.

3. The device in claim 1, wherein a metered volume of the material is delivered from the container with each actuation of the pushing mechanism.

4. The device in claim 3, wherein the metered volume is between 5 uL and 100 uL.

5. The device in claim 1, wherein the spring element is a compressive spring element.

6. The device in claim 5, wherein the compressive spring element is a compression spring.

7. The device in claim 5, wherein the compressive spring element has a spring rate of 30 lb/in to 150 lb/in.

8. The device in claim 5, wherein the compressive spring element is constrained axially in a state of compression such that the initial force to further compress the compressive spring element is a predetermined force.

9. The device in claim 8, wherein the initial force to further compress the compressive spring element is between 2 lbf and 50 lbf.

10. The device in claim 8, wherein the initial force to further compress the compressive spring element is adjustable.

11. The device in claim 1, wherein the container comprises a barrel, a stopper slideably disposed within the barrel, and an outlet.

12. The device in claim 11, wherein the plunger has a distal end that reversibly engages an end of the stopper.

13. The device in claim 12, wherein the plunger advances toward the outlet of the container and is configured to expel the material through the outlet.

14. The device in claim 11, wherein the outlet of the container communicates fluidly with a small delivery lumen.

15. The device in claim 14, wherein the small delivery lumen has an inner cross sectional area between 2.0E-4 in² and 50E-4 in².

16. The device in claim 1, wherein the structure of the eye is the suprachoroidal space.

17. The device in claim 1, wherein the structure of the eye is the Schlemm'"'"'s Canal.

18. The device in claim 1, wherein the material in the container is a viscous substance.

19. The device in claim 18, wherein the viscous substance is a viscoelastic material used during ophthalmologic surgeries.

20. The device in claim 19, wherein the viscoelastic material is mixed with pharmaceutical agents.

21. The device in claim 1, wherein the pushing mechanism includes an advancing block which applies the force to the spring element.

22. The device in claim 21, wherein the pushing mechanism further includes a ratcheting mechanism wherein the advancing block may be moved by a predetermined distance upon activation of the pushing mechanism.

23. The device in claim 22, wherein the ratcheting mechanism includes at least one latch which engages with the advancing block and is configured such that the advancing block may not move in a proximal direction.

24. The device in claim 21, wherein the pushing mechanism includes a trigger which may engage with the advancing block to advance the advancing block by a predetermined distance when actuated.

25. The device in claim 24, wherein the predetermined distance is between 0.010 in and 0.075 in.

26. The device in claim 21, wherein the pushing mechanism includes a screw mechanism wherein the advancing block moves a predetermined distance upon a given rotation of the advancing block.