Method and system for preventing migraine headaches, cluster headaches and dizziness
First Claim
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1. A method of reducing the likelihood of migraine headaches, comprising:
- providing to an individual in need thereof a buccal bioadhesive strip, said strip having a first and second side, said first side having a surface comprising a pattern defined by a plurality of spaced apart features each having at least one microscale dimension and having at least one neighboring feature having a substantially different geometry, wherein an average spacing between adjacent ones of said features is between 0.5 and 5 μ
m in at least a portion of said surface, the second side having a bioadhesive that is adapted to bind to a mucosal membrane for at least 1 hour while inside a person'"'"'s mouth, wherein said strip includes xylitol and at least one encapsulated feature containing a least one bacteria selected from the group consisting of Lachnospira, Veillonella, Faecalibacterium and Rothia, further comprising including on said strip an antibody that selectively inhibits the human calcitonin gene-related peptide (CGRP) receptor.
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Abstract
A method and system for addressing the avoidance of migraines, cluster headaches and dizziness by adjusting an individual'"'"'s microbiome, and in particular, to the provision of beneficial oral and gut microbes at particular times to enhance a person'"'"'s oral health, including through the use of oral strips that adhere to surfaces in the oral cavity.
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Citations
12 Claims
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1. A method of reducing the likelihood of migraine headaches, comprising:
providing to an individual in need thereof a buccal bioadhesive strip, said strip having a first and second side, said first side having a surface comprising a pattern defined by a plurality of spaced apart features each having at least one microscale dimension and having at least one neighboring feature having a substantially different geometry, wherein an average spacing between adjacent ones of said features is between 0.5 and 5 μ
m in at least a portion of said surface, the second side having a bioadhesive that is adapted to bind to a mucosal membrane for at least 1 hour while inside a person'"'"'s mouth, wherein said strip includes xylitol and at least one encapsulated feature containing a least one bacteria selected from the group consisting of Lachnospira, Veillonella, Faecalibacterium and Rothia, further comprising including on said strip an antibody that selectively inhibits the human calcitonin gene-related peptide (CGRP) receptor.- View Dependent Claims (3, 4, 5, 6, 7)
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2. A method of reducing the likelihood of migraine headaches, comprising:
providing to an individual in need thereof a buccal bioadhesive strip, said strip having a first and second side, said first side having a surface comprising a pattern defined by a plurality of spaced apart features each having at least one microscale dimension and having at least one neighboring feature having a substantially different geometry, wherein an average spacing between adjacent ones of said features is between 0.5 and 5 μ
m in at least a portion of said surface, the second side having a bioadhesive that is adapted to bind to a mucosal membrane for at least 1 hour while inside a person'"'"'s mouth, wherein said strip includes xylitol and at least one encapsulated feature containing a least one bacteria selected from the group consisting of Lachnospira, Veillonella, Faecalibacterium and Rothia, wherein said strip is dissolvable in a person'"'"'s mouth.- View Dependent Claims (8, 9, 10, 11, 12)
Specification