Systems and methods for high throughput analysis of conformation in biological entities
First Claim
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1. A device comprising:
- a) a substrate, the substrate comprising;
i) an M×
N array of discrete regions on a surface of the substrate, wherein M is the number of rows of discrete regions and N is the number of columns of discrete regions in the array, andii) an R×
S array of prisms integrated with the substrate and optically coupled to the discrete regions, wherein R is the number of rows of prisms and S is the number of columns of prisms in the array;
wherein each discrete region is located directly above a single prism of the array of prisms integrated with the substrate, andwherein R=M+2 and S=N, or R=M and S=N+2.
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Abstract
Methods, devices, and systems are disclosed for performing high throughput analysis of conformational change in biological molecules or other biological entities using surface-selective nonlinear optical detection techniques.
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10 Claims
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1. A device comprising:
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a) a substrate, the substrate comprising; i) an M×
N array of discrete regions on a surface of the substrate, wherein M is the number of rows of discrete regions and N is the number of columns of discrete regions in the array, andii) an R×
S array of prisms integrated with the substrate and optically coupled to the discrete regions, wherein R is the number of rows of prisms and S is the number of columns of prisms in the array;wherein each discrete region is located directly above a single prism of the array of prisms integrated with the substrate, and wherein R=M+2 and S=N, or R=M and S=N+2. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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Specification