×

Detecting and visualizing correlations between measured correlation values and correlation reference values of a pathway

  • US 9,990,713 B2
  • Filed: 06/09/2016
  • Issued: 06/05/2018
  • Est. Priority Date: 06/09/2016
  • Status: Active Grant
First Claim
Patent Images

1. A method involving a correlation value determining and visualization system, the method comprising:

  • (a) segmenting a digital image of a tissue slice of a cancer patient into first image objects representing immune cells and second image objects representing cancer cells, wherein the tissue slice was stained with a first antibody that is specific to a first protein present in immune cells, and wherein the tissue slice was stained with a second antibody that is specific to a second protein present in cancer cells;

    (b) identifying a reference correlation value from among a plurality of reference correlation values indicative of protein-protein interactions in biochemical pathways, wherein the reference correlation value is indicative of a correlation between immune cells and cancer cells;

    (c) identifying an image region in the digital image, wherein the image region is divided into a set of tiles;

    (d) generating, for each tile, a first value and a second value, wherein the first value is indicative of a density of the first image objects in the tile, and wherein the second value is indicative of a density of the second image objects in the tile;

    (e) determining, for the image region, a measured correlation value that is indicative of a relationship between the first value and the second value;

    (f) comparing the measured correlation value determined in (e) with the reference correlation value identified in (b) and thereby generating a correspondence value; and

    (g) displaying the image region on a display of the system along with an associated visual indication representing the correspondence value determined in (f), wherein (a) through (g) are performed by the system.

View all claims
  • 1 Assignment
Timeline View
Assignment View
    ×
    ×