Ion guide with orthogonal sampling
First Claim
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1. A mass spectrometer comprising:
- an RF ion guide comprising a plurality of electrodes along a length of said ion guide;
a device arranged and adapted to urge ions along at least a portion of substantially all of the length of said ion guide;
a device arranged and adapted to apply an AC or RF voltage to said electrodes in order to confine ions within said ion guide;
a device arranged and adapted to apply a DC potential to at least some of said electrodes in order to cause ions to be orthogonally sampled from said ion guide; and
a control system;
wherein;
said ions within said RF ion guide are separated with respect to their ion mobility or differential ion mobility; and
said control system is arranged and adapted to switch said ion guide to operate in a mode of operation wherein ions are orthogonally sampled from a portion of said ion guide, wherein orthogonally sampling said ions has the effect of selecting ions having ion mobilities or differential ion mobilities within a particular ion mobility or differential ion mobility range.
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Abstract
A mass spectrometer is disclosed comprising a RF ion guide wherein in a mode of operation a continuous, quasi-continuous or pulsed beam of ions is orthogonally sampled from the ion guide and wherein the continuous, quasi-continuous or pulsed beam of ions is not axially trapped or otherwise axially confined within the RF ion guide. The ion guide is maintained, in use, at a pressure selected from the group consisting of: (i) 0.0001-0.001 mbar; (ii) 0.001-0.01 mbar; (iii) 0.01-0.1 mbar; (iv) 0.1-1 mbar; (v) 1-10 mbar; (vi) 10-100 mbar; and (vii) >100 mbar.
31 Citations
17 Claims
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1. A mass spectrometer comprising:
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an RF ion guide comprising a plurality of electrodes along a length of said ion guide; a device arranged and adapted to urge ions along at least a portion of substantially all of the length of said ion guide; a device arranged and adapted to apply an AC or RF voltage to said electrodes in order to confine ions within said ion guide; a device arranged and adapted to apply a DC potential to at least some of said electrodes in order to cause ions to be orthogonally sampled from said ion guide; and a control system; wherein; said ions within said RF ion guide are separated with respect to their ion mobility or differential ion mobility; and said control system is arranged and adapted to switch said ion guide to operate in a mode of operation wherein ions are orthogonally sampled from a portion of said ion guide, wherein orthogonally sampling said ions has the effect of selecting ions having ion mobilities or differential ion mobilities within a particular ion mobility or differential ion mobility range. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method of mass spectrometry comprising:
providing an RF ion guide comprising a plurality of electrodes along a length of said ion guide; urging ions along at least a portion or substantially all of the length of said ion guide; applying an AC or RF voltage to said electrodes in order to confine ions within said RF ion guide; separating ions within said RF ion guide with respect to their ion mobility or differential ion mobility; and orthogonally sampling said ions from a portion of said RF ion guide in a mode of operation, wherein orthogonally sampling said ions has the effect of selecting ions having ion mobilities or differential ion mobilities within a particular ion mobility or differential ion mobility range. - View Dependent Claims (14, 15, 16, 17)
Specification