Magnetic resonance measurement of ultrasound properties

• US 9,993,196 B2
• Filed: 03/12/2012
• Issued: 06/12/2018
• Est. Priority Date: 03/17/2011
• Status: Active Grant

• Current Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Original Assignee: Koninklijke Philips N.V.
• Inventors: Vahala, Erkki Tapani
• Primary Examiner(s): Chen, Tse
• Assistant Examiner(s): HOFFMAN, JOANNE M
• Application Number:
  US14/005,007
• Publication Number:
  US 20130345547A1
• Time in Patent Office: 2,283 Days
• CPC Class Codes: A61B 2090/374 NMR or MRI
• CPC Class Codes: A61B 5/0036 including treatment, e.g., using an implantable medical device, ablating, ventilating
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61N 2007/0091 with moving parts, e.g. transducers, lenses, reflectors
• CPC Class Codes: A61N 2007/0095 by modifying an excitation signal
• CPC Class Codes: A61N 7/00 Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00
• CPC Class Codes: G01R 33/4808 Multimodal MR, e.g. MR combined with positron emission tomography [PET], MR combined with ultrasound or MR combined with computed tomography [CT]
• CPC Class Codes: G01R 33/56358 Elastography

Abstract

An apparatus (500, 600) comprising an ultrasound transducer element (300) for generating an ultrasonic beam (302) through a target zone (308, 538). The ultrasonic beam has an ultrasound frequency. The apparatus comprises a magnetic resonance system (502) with a resonant frequency modulator (542, 544, 516) for modulating a magnetic resonance frequency relative to a magnetic resonance of molecules in the target zone at the ultrasound frequency. Instructions cause a processor to repeatedly generate (100, 204) first gradient commands (562) which cause a magnetic field gradient coil to generate a first gradient magnetic field (710, 810) through the target zone. The gradient magnetic field has field lines directed in a first direction (304). The processor repeatedly modulates (102, 206) the magnetic resonance frequency at the ultrasound frequency, generates (104, 208) ultrasound commands (566), acquires (106, 210) magnetic resonance data from the target zone, and generates (108, 212) second gradient commands (564).

Claims

1. An apparatus comprising:

a magnetic resonance imaging system configured to image a subject in an examination zone, the magnetic resonance imaging system including gradient magnetic coils configured to generate gradient magnetic fields in the examination zone, a modulator configured to modulate the gradient magnetic fields, an RF coil, and a memory carrying machine executable instructions;

an ultrasonic transducer configured to transmit an ultrasound beam along an ultrasound beam direction into a target zone of a subject, wherein the ultrasound beam has an ultrasound frequency and wherein the target zone of the subject is in the examination zone of the magnetic resonance system; and

at least one processor configured to execute the machine executable instructions to;

concurrently control the ultrasound transducer to transmit the ultrasound beam and the modulator of the magnetic resonance system to modulate gradient magnetic fields generated by a gradient magnetic field coils with the ultrasound frequency,

generate a set of phases;

control the modulator to modulate the gradient magnetic fields at the ultrasound frequency using each phase of the set of phases during repeated application of the gradient magnetic field,

determine a magnetic resonance signal from the target zone for each phase of the set of phases,

determine a phase of the set of phases which maximizes the magnetic resonance signal,

store the determined phase which maximizes the magnetic resonance signal in the memory, and

control the magnetic resonance imaging system to generate a magnetic resonance image with the gradient magnetic field modulated at the ultrasound frequency with the determined phase which maximizes the magnetic resonance signal each time the ultrasound beam is being transmitted.

2. An apparatus comprising:

a magnetic resonance imaging system configured to image a subject in an examination zone, the magnetic resonance imaging system including gradient magnetic coils configured to generate gradient magnetic fields in the examination zone, a transceiver configured to modulate the gradient magnetic fields, an RF coil, and a memory carrying machine executable instructions;

an ultrasonic transducer configured to transmit an ultrasound beam along an ultrasound beam direction into a target zone of a subject, wherein the ultrasound beam has an ultrasound frequency and wherein the target zone of the subject is in the examination zone of the magnetic resonance system; and

at least one processor configured to execute the machine executable instructions to;

concurrently control the ultrasound transducer to transmit the ultrasound beam and the transceiver of the magnetic resonance system to modulate gradient magnetic fields generated by a gradient magnetic field coils with the ultrasound frequency,

generate a set of frequency modulation magnitudes;

control the transceiver to modulate the gradient magnetic fields in the target zone at the ultrasound frequency using each frequency modulation magnitude of the set of frequency modulation magnitudes during repeated application of the gradient magnetic field,

determine a magnetic resonance signal from the target zone for each magnitude of the set of frequency modulation magnitudes,

determine a maximizing magnitude using the set of frequency modulation magnitudes which caused the largest magnetic resonance signal from the target zone,

store the maximizing magnitude in the memory, and

control the magnetic resonance imaging system to generate a magnetic resonance image modulating the gradient magnetic field at the ultrasound frequency with the stored maximizing magnitude when the ultrasound beam is transmitted.

3. The apparatus of claim 2, wherein the at least one processor is configured to calculate an ultrasound beam amplitude for the target zone using the maximizing magnitude.

4. An apparatus comprising:

a magnetic resonance imaging system configured to image a subject in an examination zone, the magnetic resonance imaging system including gradient magnetic coils configured to generate gradient magnetic fields in the examination zone, a transceiver configured to modulate the gradient magnetic fields, an RF coil, and a memory carrying machine executable instructions;

an ultrasonic transducer configured to transmit an ultrasound beam along an ultrasound beam direction into a target zone of a subject, wherein the ultrasound beam has an ultrasound frequency and wherein the target zone of the subject is in the examination zone of the magnetic resonance system; and

at least one processor configured to execute the machine executable instructions to;

concurrently control the ultrasound transducer to transmit the ultrasound beam and the transceiver to modulate gradient magnetic fields generated by a gradient magnetic field with the ultrasound frequency,

generate a set of directions;

modulate the gradient magnetic field in the target zone at the ultrasound frequency using each direction of the set of directions during repeated application of the gradient magnetic field;

determine a magnetic resonance signal from the target zone for each direction of the set of directions;

determine the ultrasound beam direction using the magnetic resonance signal from the target zone, the ultrasound beam direction being one of the set of directions which maximizes the magnetic resonance signal from the target zone;

store the determined ultrasound beam direction which maximizes the magnetic resonance signal in the memory; and

control the magnetic resonance imaging system to generate a magnetic resonance image modulating the gradient magnetic field at the ultrasound frequency in the stored ultrasound beam direction.

5. A method of operating a magnetic resonance imaging apparatus, the method comprising:

with one or more processors executing machine executable instructions to control a magnetic field gradient coil of the magnetic resonance imaging apparatus to generate gradient magnetic fields through a target zone, wherein the target zone is a portion of a subject into which an ultrasonic beam is transmitted in an ultrasonic beam direction and wherein the gradient magnetic fields have a gradient direction parallel to the ultrasound beam direction;

with the one or more processors executing machine executable instructions to control the magnetic field gradient coil to modulate the gradient magnetic fields at the ultrasound frequency during transmission of the ultrasonic beam;

with the one or more processors executing machine executable instructions to control the magnetic field gradient coil to generate opposite polarity gradient magnetic fields through the target zone prior to the acquisition of the magnetic resonance data, wherein the opposite polarity gradient magnetic fields have a polarity opposite to that of the gradient magnetic field applied during ultrasound beam transmission;

controlling a radio frequency coil to apply a radio frequency inversion pulse between the transmission and opposite polarity gradient magnetic fields;

acquiring magnetic resonance signal from the target zone;

wherein the method further includes;

with the one or more processors executing machine executable instructions to control the magnetic field gradient coils to repeatedly modulate the gradient magnetic fields during transmission of the ultrasound beam at each phase of a set of phases or each frequency of a set of frequencies;

with the one or more processors executing machine executable instructions to determine which phase of the set of phases or which frequency of the set of frequencies maximizes the magnetic resonance signals;

with the one or more processors executing machine executable instructions to repeatedly acquire the magnetic resonance signal with the gradient magnetic field modulated with the determined phase or frequency which maximizes the magnetic resonance signal; and

with the one or more processors executing machine executable instructions to reconstruct the repeatedly acquired magnetic resonance signals into a magnetic resonance image.

6. A non-transitory computer readable storage medium including a set of instructions for execution by one or more processors of an magnetic resonance apparatus to control the magnetic resonance apparatus to perform the method of claim 5.