System and method for treating an ocular disorder

• US 9,993,368 B2
• Filed: 10/28/2010
• Issued: 06/12/2018
• Est. Priority Date: 04/14/2000
• Status: Expired due to Term

• Current Assignee: Glaukos Corporation
• Original Assignee: Glaukos Corporation
• Inventors: Bergheim, Olav B., Gharib, Morteza, Hill, Richard A.
• Primary Examiner(s): Wiest, Philip R
• Application Number:
  US12/914,940
• Publication Number:
  US 20110105987A1
• Time in Patent Office: 2,784 Days
• Field of Search: 604 8, 604 9, 604294, 606 4- 6, 606108
• CPC Class Codes: A61F 2009/00891 Glaucoma
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: A61F 9/007 Methods or devices for eye surgery
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002
• CPC Class Codes: A61K 9/0051 Ocular inserts, ocular implants
• CPC Class Codes: A61M 2210/0612 Eyes
• CPC Class Codes: A61M 27/002 Implant devices for drainage of body fluids from one part of the body to another intraocular A61F9/00781; middle ear A61F11/202
• CPC Class Codes: A61P 27/06 Antiglaucoma agents or miotics
• CPC Class Codes: Y10S 623/905 Eye

Abstract

Surgical methods and related medical devices for treating ocular disorders are disclosed. Some methods relate to delivering an implant within an eye, and involve providing an elongate guide device, such as, a flexible guide member or a guide wire. A distal end of the guide device can be advanced into an anterior chamber of an eye, or through at least a portion of a site of resistance along a physiologic outflow pathway of the eye, or from an anterior chamber of the eye to a location proximate a physiologic outflow pathway of the eye. The implant is advanced along the guide device toward the guide device distal end, and is positioned to conduct aqueous humor between the anterior chamber and the physiologic outflow pathway.

Claims

1. A method of treating an ocular disorder, comprising:

providing an ophthalmic drainage implant having a proximal section, a distal section and an internal lumen extending through the implant from at least a portion of the proximal section to at least a portion of the distal section, the ophthalmic drainage implant having a maximum cross-sectional dimension sized to allow insertion of the implant through a corneal opening into the eye to access an anterior chamber of the eye;

providing an elongate delivery member configured for ab interno insertion of the ophthalmic drainage implant and sized to extend across the anterior chamber;

coupling the ophthalmic drainage implant and the elongate delivery member such that a distal end of the elongate delivery member receives at least a portion of the internal lumen of the ophthalmic drainage implant;

advancing the elongate delivery member from an anterior chamber of an eye into a Schlemm'"'"'s canal through ocular tissue to form a drainage pathway from the anterior chamber to the Schlemm'"'"'s canal such that at least a portion of the distal section of the ophthalmic drainage implant extends into and along a portion of the Schlemm'"'"'s canal; and

removing the elongate delivery member from the eye.

2. The method of claim 1, wherein advancing the implant includes positioning the entire implant in the anterior chamber before inserting the implant into ocular tissue.

3. The method of claim 1, wherein advancing the implant includes positioning both the proximal and distal end segments of the implant in the anterior chamber.

4. The method of claim 1, further comprising positioning the distal end of the ophthalmic drainage implant canal adjacent to an aqueous collection channel.

5. The method of claim 1, wherein the corneal opening is a self-sealing incision.

6. A method of treating an ocular disorder, comprising:

forming an incision to access an anterior chamber of an eye;

penetrating ocular tissue within the eye from within the anterior chamber to form an opening into a Schlemm'"'"'s canal of the eye, thereby forming an aqueous drainage pathway from the anterior chamber to the Schlemm'"'"'s canal;

inserting an ocular drainage implant through the opening into the Schlemm'"'"'s canal; and

positioning the implant between opposing wall sections of the Schlemm'"'"'s canal so as to increase patency of the aqueous drainage pathway.

7. The method of claim 6, wherein the incision is a corneal incision.

8. The method of claim 6, wherein the incision is a self-sealing incision.

9. The method of claim 6, wherein the opening is formed within a trabecular meshwork of the eye.

10. The method of claim 6, wherein said positioning comprises positioning an end of the implant adjacent to an aqueous collection channel.

11. The method of claim 6, wherein the implant comprises at least one protrusion.

12. The method of claim 6, wherein the implant comprises an inlet and an outlet.

13. The method of claim 6, wherein inserting the ocular drainage implant through the opening into the Schlemm'"'"'s canal comprises inserting a distal section of the ocular drainage implant into the Schlemm'"'"'s canal while leaving a proximal inlet end of the ocular drainage implant within the anterior chamber.

14. The method of claim 13, wherein positioning the implant between opposing wall sections of the Schlemm'"'"'s canal so as to increase patency of the aqueous drainage pathway comprises positioning the distal section of the implant between opposing wall sections of the Schlemm'"'"'s canal.

15. The method of claim 13, wherein penetrating ocular tissue within the eye from within the anterior chamber to form the opening into the Schlemm'"'"'s canal of the eye is performed by a delivery apparatus carrying the implant.

16. The method of claim 13, wherein the distal section of the implant comprises at least one opening proximal of a distal terminus of the distal section.

17. A system for treating an ocular disorder in a patient, comprising:

a delivery device, said delivery device comprising a handpiece and an elongate delivery member; and

an ophthalmic implant comprising a body having a proximal section and a distal section with respect to the handpiece of the delivery device, at least the distal section being curved so as to fit within and extend along a portion of a Schlemm'"'"'s canal of an eye following implantation using the delivery device;

wherein the elongate delivery member is configured for ab interno insertion of the ophthalmic implant through a corneal incision and sized to extend across the anterior chamber; and

wherein the elongate delivery member is configured to retain the ophthalmic implant therein prior to implantation, and to deliver the ophthalmic implant through a trabecular meshwork of the eye and into and along the portion of the Schlemm'"'"'s canal.

18. The system of claim 17, wherein the proximal section of the body comprises an inlet and wherein the distal section of the body comprises at least one outlet.

19. The system of claim 18, wherein the ophthalmic implant has a sufficient length such that, upon implantation, the inlet of the ophthalmic drainage implant is disposed within the anterior chamber and at least a portion of the distal section of the body extends into and along the portion of the Schlemm'"'"'s canal of the eye.

20. The system of claim 17, wherein the body further comprises one or more retention features.

21. The system of claim 20, wherein the one or more retention features are selected from the group consisting of:

stubs, ribs, pillars, textured surfaces, threads, flanges, and barbs.

22. The system of claim 17, wherein the body has a generally tubular shape.

23. The system of claim 17, wherein the body has a maximum cross-sectional dimension sized to allow insertion of the body through a self-sealing opening in the eye to access the anterior chamber.

24. The system of claim 17, wherein the ophthalmic implant is made of a biocompatible, elastic material.

25. The system of claim 24, wherein a distal end of the delivery device comprises a cutting member.

26. The system of claim 17, wherein the distal section of the body comprises at least one opening proximal of a distal terminus of the distal section.