Dosage forms and related therapies
First Claim
1. A method of treatment for the prevention or amelioration of tissue damage in a subject who does not have Wilson'"'"'s disease to prevent or ameliorate tissue damage, the method comprising administering to said subject a therapeutically effective amount of a succinic acid addition salt of triethylenetetramine, wherein the tissue damage is associated with,(a) diabetic cardiomyopathy, diabetic acute coronary syndrome, diabetic hypertensive cardiomyopathy, acute coronary syndrome associated with impaired glucose tolerance, acute coronary syndrome associated with impaired fasting glucose, hypertensive cardiomyopathy associated with impaired glucose tolerance, hypertensive cardiomyopathy associated with impaired fasting glucose, ischemic cardiomyopathy associated with impaired glucose tolerance, or ischemic cardiomyopathy associated with impaired fasting glucose;
- (b) myocardial infarction, ischemic cardiomyopathy associated with coronary heart disease, cardiomyopathy, myocarditis, idiopathic cardiomyopathy, metabolic cardiomyopathy, alcoholic cardiomyopathy, drug-induced cardiomyopathy, ischemic cardiomyopathy, and hypertensive cardiomyopathy, acute coronary syndrome not associated with any abnormality of glucose metabolism, hypertensive cardiomyopathy not associated with any abnormality of glucose metabolism, or ischemic cardiomyopathy not associated with any abnormality of glucose metabolism;
or(c) disease states of an artery selected from aorta, carotid, cerebrovascular, coronary, renal, retinal, iliac, femoral, popliteal, vasa nervorum, arteriolar tree, and capillary bed, and atheromatous disorders of the major blood vessels selected from the aorta, the coronary arteries, the carotid arteries, the cerebrovascular arteries, the renal arteries, the iliac arteries, the femoral arteries, or the popliteal arteries.
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Accused Products
Abstract
This invention is directed in part to novel doses, dosage formulations, and routes of administration of such doses and dose formulations, said dose and dose formulations containing one or more copper chelators, for example, one or more trientine active agents, including trientine analogs, trientine salts, trientine prodrugs, and trientine derivatives, useful in the treatment of diseases, disorders and conditions, including in indications where copper may play a role.
58 Citations
20 Claims
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1. A method of treatment for the prevention or amelioration of tissue damage in a subject who does not have Wilson'"'"'s disease to prevent or ameliorate tissue damage, the method comprising administering to said subject a therapeutically effective amount of a succinic acid addition salt of triethylenetetramine, wherein the tissue damage is associated with,
(a) diabetic cardiomyopathy, diabetic acute coronary syndrome, diabetic hypertensive cardiomyopathy, acute coronary syndrome associated with impaired glucose tolerance, acute coronary syndrome associated with impaired fasting glucose, hypertensive cardiomyopathy associated with impaired glucose tolerance, hypertensive cardiomyopathy associated with impaired fasting glucose, ischemic cardiomyopathy associated with impaired glucose tolerance, or ischemic cardiomyopathy associated with impaired fasting glucose; -
(b) myocardial infarction, ischemic cardiomyopathy associated with coronary heart disease, cardiomyopathy, myocarditis, idiopathic cardiomyopathy, metabolic cardiomyopathy, alcoholic cardiomyopathy, drug-induced cardiomyopathy, ischemic cardiomyopathy, and hypertensive cardiomyopathy, acute coronary syndrome not associated with any abnormality of glucose metabolism, hypertensive cardiomyopathy not associated with any abnormality of glucose metabolism, or ischemic cardiomyopathy not associated with any abnormality of glucose metabolism;
or(c) disease states of an artery selected from aorta, carotid, cerebrovascular, coronary, renal, retinal, iliac, femoral, popliteal, vasa nervorum, arteriolar tree, and capillary bed, and atheromatous disorders of the major blood vessels selected from the aorta, the coronary arteries, the carotid arteries, the cerebrovascular arteries, the renal arteries, the iliac arteries, the femoral arteries, or the popliteal arteries. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification