Assembly with a guide tube, a fixator for attaching to a blood vessel, and a pump

• US 9,993,622 B2
• Filed: 05/15/2013
• Issued: 06/12/2018
• Est. Priority Date: 05/16/2012
• Status: Active Grant

• Current Assignee: Endovascular Development AB
• Original Assignee: Endovascular Development AB
• Inventors: Liungman, Krister
• Primary Examiner(s): Bosques, Edelmira
• Application Number:
  US14/401,488
• Publication Number:
  US 20150126965A1
• Time in Patent Office: 1,854 Days
• Field of Search: 604509
• CPC Class Codes: A61M 2025/0681 Systems with catheter and outer tubing, e.g. sheath, sleeve or guide tube
• CPC Class Codes: A61M 25/04 in the body, e.g. expansible A61M25/10, A61M16/0488 take precedence
• CPC Class Codes: A61M 25/0662 Guide tubes

Abstract

A fixator assembly comprising a fixator for fixing inside a blood vessel, a guide tube attached to the fixator and a pump for supplying a liquid to the blood vessel or from the blood vessel via the guide tube. Blood flow past the fixator is possible during pumping so that critical situations are avoided. A method of providing a liquid to a blood vessel using the assembly is also claimed. Sampling or liquid dosing thus may be performed during extended periods of time while performing this at a well-defined position in the blood vessel and potentially close to or at the desired position in the person.

Claims

1. An assembly, comprising:

a guide tube having a distal end for introduction into a blood vessel and a proximal end;

a fixator attached to the guide tube and configured to releasably attach to an inner side of the blood vessel, the fixator being configured to allow blood flow in the blood vessel during transport of liquid to or from the blood vessel, the fixator including

a deformable portion having a central portion configured to attach to the inner side of the blood vessel at a length thereof, along a first longitudinal direction of the blood vessel,

a distal part attached to the deformable portion, the distal part including a distal sleeve configured to slide relative to the guide tube, and

a proximal part attached to the deformable portion, the proximal part including a proximal sleeve configured to slide relative to the guide tube;

a pump configured to transport a liquid to the blood vessel through the guide tube or from the blood vessel through the guide tube; and

a stopper fixed to the guide tube and configured to prevent the fixator from travelling distally beyond the stopper based on restricting the distal sleeve from sliding distally relative to the stopper,

wherein,

the fixator is configured to move toward the proximal end of the guide tube independently of the guide tube and unrestricted by the stopper, concurrently with the fixator maintaining attachment to the inner side of the blood vessel and based on the proximal sleeve and the distal sleeve sliding relative to the guide tube.

2. The assembly according to claim 1, wherein the deformable portion defines, when projected on to a plane perpendicular to the first longitudinal direction and in a rest position, a circumscribed portion with a first area and a cross section being less than 15% of the first area.

3. The assembly according to claim 1, wherein the deformable portion defines, when projected on to a plane perpendicular to the first longitudinal direction and in a rest position, a circumscribed portion with a first area.

4. The assembly according to claim 1, wherein the deformable portion defines, when projected on to a plane perpendicular to the first longitudinal direction and in a rest position, a circumscribed portion with a first area and wherein the fixator defines, when projected on to the plane and in the rest position, a cross section being less than 75% of the first area.

5. The assembly according to claim 1, wherein the deformable portion is adapted to exert at least substantially a common same force to the blood vessel along all of a particular length when a pulling force of at least 0.1N is exerted to the guide tube and fixator.

6. The assembly according claim 1, wherein,

the central portion of the deformable portion circumscribing, in a plane perpendicular to a second longitudinal axis, a larger cross section when a first distance exists between the proximal and distal parts compared to when a second distance exists between the proximal and distal parts, the second distance being larger than the first distance.

7. The assembly according to claim 6, wherein,

the central portion has a rest shape,

the rest shape circumscribes a first cross sectional area in a particular plane perpendicular to the second longitudinal axis and at a first position along the second longitudinal axis,

the rest shape circumscribes a second cross sectional area in a separate plane perpendicular to the second longitudinal axis and at a second position along the second longitudinal axis, and

the second position is closer to the distal part than the first position, the second cross sectional area being smaller than the first cross sectional area.

8. The assembly according claim 6, wherein the central portion is configured to, based on the proximal part and the distal part being forced toward each other along the second longitudinal axis,

circumscribe a third cross sectional area in a particular plane perpendicular to the second longitudinal axis and at a third position along the second longitudinal axis, and

circumscribe a fourth cross sectional area in a separate plane perpendicular to the second longitudinal axis and at a fourth position along the second longitudinal axis,

wherein the third position is closer to the distal part than the fourth position, the third cross sectional area being smaller than the fourth cross sectional area.

9. The assembly according to claim 6, wherein the deformable portion comprises a wire mesh, and wherein a wire density of the wire mesh is higher at the distal end, than at the proximal end.

10. The assembly according to claim 7, wherein the deformable portion comprises a tube mesh, and wherein a tube thickness of the tube mesh is higher at one of the distal end and the second position than at one of the proximal end and the first position.

11. The assembly according to claim 8, further comprising a circumference limiting element at one of the distal end, the second position and the third position.

12. The assembly according to claim 1, wherein the guide tube comprises multiple lumens, the pump being configured to transport liquid to or from the blood vessel via a first of the lumens, and wherein at least two lumens open, at the distal end, up toward the blood vessel at different longitudinal positions along a longitudinal direction of the guide tube at the distal end.

13. The assembly according to claim 1, wherein the proximal end of the guide tube is configured to remain outside of a body while the fixator is positioned in a blood vessel of the body.

14. The assembly according to claim 1, further comprising:

a retrieving catheter and a delivery catheter, wherein the guide tube, the retrieving catheter and the delivery catheter have lengths of 0.5-2.8 m, respectively.

15. The assembly according to claim 1, wherein the fixator is configured to maintain attachment to the inner side of the blood vessel, based on a pulling force of at least 0.1N being applied to the guide tube and, via the stopper, to the fixator.

16. A method of providing a liquid to a blood vessel of a body or removing liquid from the blood vessel of the body, the method comprising:

providing a fixator connected to a stopper at a distal end of a guide tube, the stopper fixed to the guide tube, the guide tube also having a proximal end, the fixator including

a deformable portion having a central portion configured to attach to an inner side of the blood vessel at a length thereof, along a first longitudinal direction of the blood vessel,

a distal part attached to the deformable portion, the distal part including a distal sleeve configured to slide relative to the guide tube, and

a proximal part attached to the deformable portion, the proximal part including a proximal sleeve configured to slide relative to the guide tube;

positioning the fixator and the distal end of the guide tube within the blood vessel of the body so that the proximal end of the guide tube is positioned outside the body;

detaching the fixator from the stopper, such that

the stopper prevents the fixator from travelling distally beyond the stopper, and

the fixator is configured to move toward the proximal end of the guide tube independently of the guide tube and unrestricted by the stopper, concurrently with the fixator maintaining attachment to the inner side of the blood vessel; and

introducing the liquid into the blood vessel or withdrawing liquid from the blood vessel of the body via the guide tube while allowing blood flow in the blood vessel of the body.

17. The method according to claim 16, wherein the positioning includes introducing the fixator and distal end into a second blood vessel of the body and guiding the fixator and distal end to the blood vessel of the body via the second blood vessel of the body.

18. The method of claim 16, wherein the introducing or withdrawing is performed intermittently over time.

19. The method of claim 16, wherein the introducing or withdrawing is performed over a period of time of at least 10 minutes.

20. The method of claim 16, further comprising:

providing a camera through the guide tube from the proximal end to the distal end and providing image data from the blood vessel of the body at the distal end.