Low level light therapy for enhancement of neurologic function by altering axonal transport rate

• US 9,993,659 B2
• Filed: 06/16/2010
• Issued: 06/12/2018
• Est. Priority Date: 11/01/2001
• Status: Active Grant

• Current Assignee: Photothera IP Holdings, Inc., Pthera,Llc
• Original Assignee: Pthera,Llc
• Inventors: Streeter, Jackson, De Taboada, Luis
• Primary Examiner(s): Downey, John R
• Application Number:
  US12/817,090
• Publication Number:
  US 20110144723A1
• Time in Patent Office: 2,918 Days
• Field of Search: 128898, 606 2- 19, 607 88- 94
• CPC Class Codes: A61N 2005/063 comprising light transmitting means, e.g. optical fibres
• CPC Class Codes: A61N 2005/0645 Applicators worn by the patient
• CPC Class Codes: A61N 2005/0659 infrared
• CPC Class Codes: A61N 5/0618 Psychological treatment
• CPC Class Codes: A61N 5/067 using laser light

Abstract

Methods of altering the rate of axonal transport are provided in several embodiments. Some embodiments alter axonal transport in a patient in need of an enhancement of axonal transport to alleviate symptoms of a disease or injury. The methods further include delivering electromagnetic radiation to at least one portion of the brain, spinal cord, or peripheral nervous system of a patient sufficient to effect an alteration in axonal transport in the patient.

Claims

1. A method for enhancing axonal transport in an impaired neuron, the method comprising:

providing a low level light therapy (LLLT) device, wherein the LLLT device has a light emitting surface that emits light;

identifying one or more neurons having impaired axonal transport;

delivering the light to the one or more neurons; and

determining the rate of axonal transport in one or more of the one or more neurons in response to the delivery of the light and adjusting the light in response to the determined rate of axonal transport,

wherein the light has a wavelength between 630 nm and 1064 nm,

wherein the light has an irradiance at the light emitting surface of 10 mW/cm² to 10000 mW/cm², and

wherein the light enhances one or more of the velocity of axonal transport in one or more of the one or more neurons, the average distance of axonal transport in one or more of the one or more neurons, and the total distance of axonal transport in one or more of the one or more neurons, thereby enhancing axonal transport in one or more of the one or more neurons.

2. The method of claim 1, wherein the light has an irradiance at or within one centimeter of one or more of the one or more neurons of 20 mW/cm² to 60 mW/cm².

3. The method of claim 2, wherein the light has an irradiance at or within one centimeter of one or more of the one or more neurons of 50 mW/cm².

4. The method of claim 1, wherein the axonal transport in one or more of the one or more neurons is impaired by at least 10% as compared to axonal transport in a healthy neuron.

5. The method of claim 1, wherein the axonal transport in one or more of the one or more neurons after delivering the light is comparable to axonal transport in healthy neurons.

6. The method of claim 1, wherein the enhancement of axonal transport enhances transport of one or more mitochondria along an axon of one or more of the one or more neurons.

7. The method of claim 1, wherein the light has a wavelength of 810 nm.

8. The method of claim 1, wherein the one or more neurons comprise at least one of a peripheral neuron, sensory neuron, motor neuron, and inter neuron.

9. The method of claim 1, wherein one or more of the one or more neurons are associated with cognitive function.

10. The method of claim 1, further comprising identifying a patient having Parkinson'"'"'s disease, and delivering the light to the patient.

11. The method of claim 1, further comprising:

identifying a patient having a neurological impairment,

wherein the neurological impairment is selected from the group consisting of Alzheimer'"'"'s disease, Huntington'"'"'s disease, dopaminergic impairment, and amyotrophic lateral sclerosis; and

delivering the light to the patient.

12. The method of claim 1, wherein the enhancement of axonal transport comprises increasing the rate of axonal transport.

13. The method of claim 1, wherein enhancing the rate of axonal transport comprises accelerating the clearance of a substance from one or more of the one or more neurons.

14. The method of claim 1, wherein the light is delivered continuously.

15. The method of claim 1, wherein the light is delivered in pulses.

20. The method of claim 1, wherein the light has a peak irradiance at the light emitting surface of 10 mW/cm² to 10000 mW/cm².

21. The method of claim 1, wherein the light has a wavelength between 800 nm and 815 nm, and wherein the light has an irradiance at the light emitting surface of 1400 mW/cm² to 4200 mW/cm².

16. A method for enhancing axonal transport in a neuron, the method comprising:

providing a low level light therapy (LLLT) device, wherein the LLLT device has a light emitting surface that emits light;

delivering the light to at least one neuron; and

determining the rate of axonal transport in the neuron in response to the delivery of the light and adjusting the light in response to the determined rate of axonal transport,

wherein the light has a wavelength between 630 nm and 1064 nm,

wherein the light has an irradiance at or within one centimeter of the neuron of 20 mW/cm² to 60 mW/cm², and

wherein the light enhances axonal transport in the neuron by enhancing one or more of the following;

velocity of axonal transport, average distance of axonal transport, and total distance of axonal transport.

17. The method of claim 16, wherein the light is delivered in pulses at a frequency ranging from 80 to 120 Hertz.

18. A method for enhancing neuronal axonal transport in a patient having one or more symptoms of Parkinson'"'"'s disease, the method comprising:

identifying a patient with one or more symptoms of Parkinson'"'"'s disease;

providing a low level light therapy (LLLT) device, wherein the LLLT device has a light emitting surface that emits light,

wherein the LLLT device is configured for delivering light to a plurality of neurons in the patient;

delivering the light to the patient; and

determining the rate of axonal transport in one or more of the plurality of neurons in response to the delivery of the light and adjusting the light in response to the determined rate of axonal transport,

wherein the light has a wavelength between 630 nm and 1064 nm,

wherein the light has an irradiance at the light emitting surface of 10 mW/cm² to 10000 mW/cm², and

wherein the light enhances one or more of the velocity of axonal transport in one or more of the plurality of neurons, the average distance of axonal transport in one or more of the plurality of neurons, and the total distance of axonal transport in one or more of the plurality of neurons, thereby enhancing axonal transport in one or more of the plurality of neurons and improving one or more symptoms of Parkinson'"'"'s disease.

19. The method of claim 18, wherein one or more of the plurality of neurons are dopaminergic neurons and the enhanced axonal transport increases the delivery of dopamine to the synapse of the dopaminergic neurons.