Biologic fluid analysis cartridge

• US 9,993,817 B2
• Filed: 01/31/2017
• Issued: 06/12/2018
• Est. Priority Date: 12/18/2009
• Status: Active Grant

• Current Assignee: Abbott Point Of Care Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Point Of Care Incorporated (Abbott Laboratories Incorporated)
• Inventors: Verrant, John A., Blum, John N., Phan, Vu, Verma, Kaushal K., Edson, Elise G.
• Primary Examiner(s): Siefke, Samuel P
• Application Number:
  US15/420,388
• Publication Number:
  US 20170136459A1
• Time in Patent Office: 497 Days
• CPC Class Codes: B01F 2101/23 Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
• CPC Class Codes: B01F 25/4314 with helical baffles
• CPC Class Codes: B01F 25/4316 the baffles being flat pieces of material, e.g. intermeshing, fixed to the wall or fixed on a central rod
• CPC Class Codes: B01F 25/43195 Wires or coils
• CPC Class Codes: B01F 25/431951 Spirally-shaped baffle
• CPC Class Codes: B01F 25/433 Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
• CPC Class Codes: B01F 25/4331 Mixers with bended, curved, coiled, wounded mixing tubes or comprising elements for bending the flow
• CPC Class Codes: B01F 25/4335 Mixers with a converging-diverging cross-section
• CPC Class Codes: B01F 33/30 Micromixers
• CPC Class Codes: B01L 2200/027 for microfluidic devices
• CPC Class Codes: B01L 2200/028 Modular arrangements
• CPC Class Codes: B01L 2200/0621 Control of the sequence of chambers filled or emptied
• CPC Class Codes: B01L 2200/0684 Venting, avoiding backpressure, avoid gas bubbles
• CPC Class Codes: B01L 2300/045 whereby the whole cover is slidable
• CPC Class Codes: B01L 2300/0681 Filter
• CPC Class Codes: B01L 2300/0816 Cards, e.g. flat sample carriers usually with flow in two horizontal directions
• CPC Class Codes: B01L 2300/0867 Multiple inlets and one sample wells, e.g. mixing, dilution
• CPC Class Codes: B01L 2300/168 Specific optical properties, e.g. reflective coatings
• CPC Class Codes: B01L 2400/0406 capillary forces
• CPC Class Codes: B01L 2400/0478 pistons
• CPC Class Codes: B01L 2400/0481 : squeezing of channels or chambers
• CPC Class Codes: B01L 2400/0484 : Cantilevers
• CPC Class Codes: B01L 2400/0487 : fluid pressure, pneumatics
• CPC Class Codes: B01L 2400/0633 : with moving parts
• CPC Class Codes: B01L 2400/065 : sliding valves
• CPC Class Codes: B01L 2400/0655 : pinch valves
• CPC Class Codes: B01L 2400/086 : using baffles or other fixed flow obstructions
• CPC Class Codes: B01L 3/502707 : characterised by the manufacture of the container or its components by shaping or joining plastic parts B29C59/00, B29C65/00; by laminating B32B37/00; manufacture of microstructural devices in general B81C
• CPC Class Codes: B01L 3/502715 : characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
• CPC Class Codes: B01L 3/50273 : characterised by the means or forces applied to move the fluids micropumps F04B19/006, of the membrane type F04B43/043

Abstract

A biological fluid sample analysis cartridge is provided. The cartridge includes a housing, a fluid module, and an analysis chamber. The fluid module includes a sample acquisition port and an initial channel, and is connected to the housing. The initial channel is sized to draw fluid sample by capillary force, and is in fluid communication with the acquisition port. The initial channel is fixedly positioned relative to the acquisition port such that at least a portion of a fluid sample disposed within the acquisition port will draw into the initial channel. The analysis chamber is connected to the housing, and is in fluid communication with the initial channel.

Claims

1. A biological fluid sample analysis cartridge, comprising:

a housing;

a fluid module having a sample acquisition port and an initial channel, which fluid module is connected to the housing, and which initial channel is in fluid communication with the acquisition port; and

an imaging tray having an analysis chamber, which tray is selectively positionable relative to the housing in an open position and a closed position, and in the closed position, the analysis chamber is in fluid communication with the initial channel;

wherein the analysis chamber includes a first panel and a second panel, the first panel and second panel both being transparent and substantially aligned with one another, wherein the alignment between the panels defines an area wherein light transmitted perpendicular to one of the first or second panels will pass through that panel, the biological fluid sample, and the other of the first or second panels.

2. The cartridge of claim 1, wherein the imaging tray is selectively lockable in the closed position, in which position it is disposed within the housing.

3. The cartridge of claim 1, further comprising a magnetically actuable latch selectively operable to lock or unlock the imaging tray in the closed position.

4. A biological fluid sample analysis cartridge, comprising:

a housing having a sample acquisition port and an initial channel, which initial channel is in fluid communication with the acquisition port; and

an imaging tray having an analysis chamber;

wherein the imaging tray is in contact with the housing and translatable between an open position wherein at least a portion of the analysis chamber is disposed outside of the housing and is exposed, and a closed position wherein the analysis chamber in disposed within the housing;

wherein the analysis chamber includes a first panel and a second panel, the first panel and second panel both being transparent and substantially aligned with one another, wherein the alignment between the panels defines an area wherein light transmitted perpendicular to one of the first or second panels will pass through that panel, the biological fluid sample, and the other of the first or second panels.

5. The cartridge of claim 4, wherein in the closed position the analysis chamber is in fluid communication with the initial channel.

6. The cartridge of claim 4, further comprising a secondary channel in fluid communication with the initial channel, wherein an intersection between the secondary channel and the initial channel is configured to prevent capillary fluid flow between the initial channel and the secondary channel.

7. The cartridge of claim 6, further comprising a sample port in fluid communication with the secondary channel and positioned to be aligned with the analysis chamber when the imaging tray is disposed in the closed position.

8. The cartridge of claim 7, wherein the sample port is configured to permit fluid sample travel within the sample port by capillary force.

9. The cartridge of claim 6, wherein the secondary channel is configured to permit oscillatory fluid sample movement within the secondary channel.

10. The cartridge of claim 6, further comprising an exhaust port in fluid communication with the secondary channel, which said exhaust port is configured to penult gas within the secondary channel to exit the secondary channel and to inhibit liquid from exiting the secondary channel.

11. The cartridge of claim 10, further comprising a gas permeable and liquid impermeable membrane disposed relative to the exhaust port.

12. The cartridge of claim 4, wherein the imaging tray includes a first side rail, a second side rail, and a widthwise extending end rail, and the analysis chamber extends between the first side rail and the second side rail.

13. The cartridge of claim 12, wherein the imaging tray includes at least one latch member configured to selectively secure the imaging tray to the housing.