Automated reagent manager of a diagnostic analyzer system

• US 9,993,820 B2
• Filed: 03/14/2014
• Issued: 06/12/2018
• Est. Priority Date: 03/15/2013
• Status: Active Grant

• Current Assignee: Abbott Laboratories Incorporated
• Original Assignee: Abbott Laboratories Incorporated
• Inventors: Donohue, Joseph P., Rai, Surya Pratap
• Primary Examiner(s): Soohoo, Tony G
• Assistant Examiner(s): Insler, Elizabeth
• Application Number:
  US14/214,019
• Publication Number:
  US 20140286124A1
• Time in Patent Office: 1,551 Days
• Field of Search: 366208-211, 366220
• CPC Class Codes: B01L 2200/023 adapted for different sizes of tubes, tips or container
• CPC Class Codes: B01L 2200/025 Align devices or objects to ensure defined positions relative to each other
• CPC Class Codes: B01L 2300/041 Connecting closures to device or container
• CPC Class Codes: B01L 3/52 Containers specially adapted for storing or dispensing a reagent B01L3/02 takes precedence; containers for medical or pharmaceutical purposes A61J1/00; containers in general B65D; storing or dispensing test elements G01N33/4875; automated reagent dispensing G01N35/1002
• CPC Class Codes: B01L 3/523 with means for closing or opening
• CPC Class Codes: B01L 9/50 Clamping means, tongs in general F16B2/06
• CPC Class Codes: G01N 2035/00524 Mixing by agitating sample carrier
• CPC Class Codes: G01N 35/1002 Reagent dispensers

Abstract

A reagent manager for a diagnostic analyzer system includes a reagent manager housing, a high-speed reagent bottle spinning device, a processor, and a memory. The reagent manager housing is for housing reagent bottles. The high-speed reagent bottle spinning device is disposed within the reagent manager housing for spinning at least one of the reagent bottles. The processor is in electronic communication with the high-speed reagent bottle spinning device. The memory is in electronic communication with the processor. The memory includes programming code for execution by the processor. The programming code is configured to spin the high-speed reagent bottle spinning device to spin the at least one reagent bottle to remove microparticles from a bottom surface of a septum of the at least one reagent bottle.

Claims

1. A method of removing microparticles from a reagent storage container septum comprising:

providing a reagent bottle having microparticles accumulated to an inner surface of a septum, the inner surface configured to allow a pipetting device to access within the reagent bottle, and having liquid disposed within the reagent bottle;

spinning the reagent bottle, around an axis through the reagent bottle, at a first speed in a plurality of cycles thereby causing a turbulent flow of the liquid within the reagent bottle causing the liquid to contact and remove the microparticles from the inner surface of the septum of the reagent bottle; and

subsequently spinning the reagent bottle, around an axis through the reagent bottle, at a second speed, lower than the first speed, to disperse the microparticles, removed from the inner surface of the septum, within the liquid disposed within the reagent bottle.

2. The method of claim 1 wherein the spinning the reagent bottle at the first speed in the plurality of cycles to cause the turbulent flow of the liquid comprises spinning the reagent bottle clockwise and counter-clockwise to move the liquid disposed within the reagent bottle clockwise and counter-clockwise at a speed rate of between 5,000 degrees per second to 7,000 degrees per second, at an acceleration rate of between 110,000 degrees per second squared to 180,000 degrees per second squared, and in a rotation of between 180 degrees to 360 degrees.

3. The method of claim 1 wherein the spinning the reagent bottle at the first speed in the plurality of cycles to cause the turbulent flow of the liquid further comprises having a delay in a range of between 250 milliseconds to 750 milliseconds in-between clockwise and counter-clockwise cycles.

4. The method of claim 1 wherein the spinning the reagent bottle at the first speed in the plurality of cycles to cause the turbulent flow of the liquid further comprises spinning the reagent bottle in a range of 40 to 80 clockwise and counter-clockwise cycles.

5. The method of claim 1 wherein the reagent bottle comprises at least one fin disposed within the reagent bottle, the at least one fin being disposed at an angle of 90 degrees relative to an outer surface of the reagent bottle.

6. The method of claim 1 wherein the reagent bottle comprises two fins disposed within the reagent bottle, the two fins being disposed at an angle of 90 degrees relative to an outer surface of the reagent bottle.

7. The method of claim 1 further comprising:

spinning the reagent bottle, in between a first set of clockwise and counter-clockwise cycles, in a first number of consecutive, plural one-directional rotations to de-foam the liquid; and

spinning the reagent bottle, in between a second set of clockwise and counter-clockwise cycles, in a second number of consecutive, plural one-directional rotations, different than the first number, to de-foam the liquid.

8. The method of claim 1 wherein the providing the reagent bottle having microparticles accumulated to the inner surface of the septum, the inner surface configured to allow the pipetting device to access within the reagent bottle, and having liquid disposed within the reagent bottle further comprises accumulating the microparticles on the inner surface of the septum of the reagent bottle during shipping of the reagent bottle.

9. The method of claim 1 wherein the spinning the reagent bottle at the first speed in the plurality of cycles to cause the turbulent flow of the liquid is done at a first location of a reagent manager, and the subsequently spinning the reagent bottle at the second speed, lower than the first speed, to disperse the microparticles, removed from the inner surface of the septum, within the liquid disposed within the reagent bottle is done at a second location of the reagent manager.

10. The method of claim 2 wherein the spinning the reagent bottle at the first speed in the plurality of cycles to cause the turbulent flow of the liquid further comprises spinning the reagent bottle in a range of 40 to 80 clockwise and counter-clockwise cycles.

11. The method of claim 10 wherein the spinning the reagent bottle at the first speed in the plurality of cycles to cause the turbulent flow of the liquid further comprises having a delay in a range of between 250 milliseconds to 750 milliseconds in-between clockwise and the counter-clockwise cycles.

12. The method of claim 1 further comprising a reagent cartridge holding the reagent bottle during both the spinning the reagent bottle at the first speed and the spinning the reagent bottle at the second speed.

13. The method of claim 12 further comprising the reagent bottle spinning relative to the reagent cartridge at both the first speed and the second speed.

14. The method of claim 13 wherein both the spinning the reagent bottle at the first speed and the spinning the reagent bottle at the second speed comprise a gear rotating a dispersion gear of the reagent cartridge and the dispersion gear of the reagent cartridge spinning the reagent bottle held by the reagent cartridge.

15. The method of claim 9 further comprising automatically moving the reagent bottle between the first location and the second location of the reagent manager.