Compositions and methods for modulating growth hormone receptor expression
First Claim
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1. A compound comprising a modified oligonucleotide and a conjugate group, wherein the modified oligonucleotide is 15 to 30 linked nucleosides in length and wherein the modified oligonucleotide has a nucleobase sequence comprising a portion of at least 15 contiguous nucleobases 100% complementary to an equal length portion of nucleobases 153921-153940 of SEQ ID NO:
- 2.
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Abstract
The present embodiments provide methods, compounds, and compositions for treating, preventing, ameliorating a disease associated with excess growth hormone using antisense compounds oligonucleotides targeted to growth hormone receptor (GHR).
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43 Claims
- 1. A compound comprising a modified oligonucleotide and a conjugate group, wherein the modified oligonucleotide is 15 to 30 linked nucleosides in length and wherein the modified oligonucleotide has a nucleobase sequence comprising a portion of at least 15 contiguous nucleobases 100% complementary to an equal length portion of nucleobases 153921-153940 of SEQ ID NO:
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22. A compound consisting of
(a) a conjugate group and (b) a modified oligonucleotide of nucleobases of SEQ ID NO: - 703 according to the following formula;
mCes mCes Aes mCes mCes Tds Tds Tds Gds Gds Gds Tds Gds Ads Ads Tes Aes Ges mCes Ae;
wherein,A=an adenine, mC=a 5-methylcytosine G=a guanine, T=a thymine, e=a 2′
-O-methoxyethyl modified nucleoside,d=a 2′
-deoxynucleoside, ands=a phosphorothioate internucleoside linkage.
- 703 according to the following formula;
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23. A compound consisting of a conjugate group and a modified oligonucleotide of nucleobases of SEQ ID NO:
- 703 according to the following formula;
- View Dependent Claims (26)
- 703 according to the following formula;
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35. A compound consisting of a modified oligonucleotide and a conjugate group, wherein the modified oligonucleotide is 20 linked nucleosides in length and consists of the sequence of SEQ ID NO:
- 703, wherein the modified oligonucleotide consists of
a gap segment consisting of ten linked deoxynucleosides; a 5′
wing segment consisting of five linked nucleosides; anda 3′
wing segment consisting of five linked nucleosides;wherein the gap segment is positioned between the 5′
wing segment and the 3′
wing segment, wherein each nucleoside of each wing segment comprises a 2′
-MOE sugar, wherein each internucleoside linkage is a phosphorothioate linkage;
wherein each cytosine is a 5-methylcytosine; and
wherein the conjugate group is - View Dependent Claims (42)
- 703, wherein the modified oligonucleotide consists of
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43. A compound comprising a modified oligonucleotide, wherein the modified oligonucleotide is 20 linked nucleosides in length and consists of the sequence of SEQ ID NO:
- 703, wherein the modified oligonucleotide consists of
a gap segment consisting of ten linked deoxynucleosides; a 5′
wing segment consisting of five linked nucleosides; anda 3′
wing segment consisting of five linked nucleosides;wherein the gap segment is positioned between the 5′
wing segment and the 3′
wing segment, wherein each nucleoside of each wing segment comprises a 2′
-MOE sugar, wherein each internucleoside linkage is a phosphorothioate linkage; and
wherein each cytosine is a 5-methylcytosine.
- 703, wherein the modified oligonucleotide consists of
Specification