Nanoparticle compositions
First Claim
1. A pharmaceutical composition comprising:
- (a) a plurality of nanoparticles, each of which is comprised of a biodegradable or biocompatible polymer arranged in a nanoparticle structure whose external surface-is coated with(i) a preparation comprising a crude hydrophobic bacterial extract; and
(ii) a hydrophilic antigen encapsulated by the nanoparticle structure so that, when the nanoparticle composition is administered to a subject, the antigen is hidden from immune system components; and
(b) at least one pharmaceutically acceptable excipient.
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Accused Products
Abstract
The present invention provides, among other things, nanoparticle compositions including a plurality of nanoparticles, each of which is comprised of a biodegradable or biocompatible polymer arranged in a nanoparticle structure defining an internal lumen and an external surface and one or more of a preparation of hydrophilic cellular components and a preparation of hydrophobic cellular components. In some embodiments, the preparation of hydrophilic cellular components is encapsulated within the internal lumen and the preparation of hydrophobic cellular components is associated with the external surface. Various methods of making and using disclosed nanoparticle compositions are also provided.
177 Citations
9 Claims
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1. A pharmaceutical composition comprising:
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(a) a plurality of nanoparticles, each of which is comprised of a biodegradable or biocompatible polymer arranged in a nanoparticle structure whose external surface-is coated with (i) a preparation comprising a crude hydrophobic bacterial extract; and (ii) a hydrophilic antigen encapsulated by the nanoparticle structure so that, when the nanoparticle composition is administered to a subject, the antigen is hidden from immune system components; and (b) at least one pharmaceutically acceptable excipient. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A method comprising:
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treating a human subject suffering from or susceptible to at least two distinct allergic conditions by administering to a human subject in need thereof at least one nanoparticle composition comprising a plurality of nanoparticles, each of which is comprised of a biodegradable or biocompatible polymer arranged in a nanoparticle structure whose external surface is coated with a preparation comprising a crude hydrophobic bacterial extract; and a hydrophilic antigen encapsulated by the nanoparticle structure so that, when the nanoparticle composition is administered to the human subject, the antigen is hidden from the subject'"'"'s immune system components. - View Dependent Claims (8)
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9. A nanoparticle composition comprising:
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a plurality of nanoparticles, each of which is comprised of; (a) poly(lactic-co-glycolic acid) arranged in a nanoparticle structure whose external surface-is coated with a preparation comprising a crude hydrophobic bacterial extract; and (b) a hydrophilic antigen, which antigen is selected from the group consisting of;
an allergic antigen, an anaphylactic antigen, an infectious antigen, an autoantigen, a disease-associated antigen, a food antigen, a microbial antigen, a viral antigen, a tumor antigen, and an environmental antigen, and(c) one or more hydrophilic cellular components, wherein the hydrophilic antigen and cellular components are encapsulated by the nanoparticle structure so that, when the nanoparticle composition is administered to a subject, the antigen is hidden from immune system components.
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Specification