Systems and method for deep brain stimulation therapy
First Claim
1. A method for performing deep brain stimulation (DBS) therapy, the method comprising:
- pre-operatively acquiring at least one pre-operative image of a brain of a patient with at least one imaging sub-system;
determining a location of a Nucleus Basalis of Meynert (NBM) for therapy in the at least one pre-operative image;
infra-operatively acquiring at least one intra-operative image of the brain after obtaining an access opening through a skull of the patient;
performing surgical planning based on the pre-operative image and the intra-operative image;
advancing a lead having deep brain stimulation (DBS) electrodes to a target position proximate to or within the NBM area;
coupling the lead to an implantable pulse generator (IPG) configured to deliver DBS pulses through the DBS electrodes to the NBM, the IPG to deliver DBS pulses for treating symptoms associated with Alzheimer'"'"'s Disease (AD); and
wherein the surgical planning and advancing operations locate the DBS electrodes such that a Nucleus Accumbens (NAcc) and the NBM are both located within an energy trajectory of the DBS delivered by, and propagating from, the DBS electrodes.
1 Assignment
0 Petitions
Accused Products
Abstract
A system and method for performing deep brain stimulation (DBS) therapy are provided. The method and system include pre-operatively acquiring at least one pre-operative image of the brain with at least one imaging sub-system and determining a location of a Nucleus Basalis of Meynert (NBM) for therapy in the at least one pre-operative image, and intra-operatively acquiring at least one intra-operative image of the brain after obtaining an access opening through the skull. The method and system further provide performing surgical planning based on the pre-operative image in the intra-operative image, advancing a lead having DBS electrodes on the lead to a target position proximate to or within the NBM area, and coupling the lead to an implantable pulse generator (IPG) configured to deliver DBS pulses through the DBS electrodes to the NBM. Further, the IPG is configured to deliver DBS pulses for treating symptoms associated with Alzheimer'"'"'s disease.
-
Citations
20 Claims
-
1. A method for performing deep brain stimulation (DBS) therapy, the method comprising:
-
pre-operatively acquiring at least one pre-operative image of a brain of a patient with at least one imaging sub-system; determining a location of a Nucleus Basalis of Meynert (NBM) for therapy in the at least one pre-operative image; infra-operatively acquiring at least one intra-operative image of the brain after obtaining an access opening through a skull of the patient; performing surgical planning based on the pre-operative image and the intra-operative image; advancing a lead having deep brain stimulation (DBS) electrodes to a target position proximate to or within the NBM area; coupling the lead to an implantable pulse generator (IPG) configured to deliver DBS pulses through the DBS electrodes to the NBM, the IPG to deliver DBS pulses for treating symptoms associated with Alzheimer'"'"'s Disease (AD); and wherein the surgical planning and advancing operations locate the DBS electrodes such that a Nucleus Accumbens (NAcc) and the NBM are both located within an energy trajectory of the DBS delivered by, and propagating from, the DBS electrodes. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
-
-
10. A system for performing deep brain stimulation (DBS) therapy, the system comprising:
-
a surgical planning (SP) work station having an input configured to receive at least one pre-operative image of a brain of a patient with at least one imaging sub-system; the SP work station configured to permit a user to determine a location of a Nucleus Basalis of Meynert (NBM) for therapy in the at least one pre-operative image; the SP work station having an input configured to receive at least one intra-operative image of the brain after obtaining an access opening through a skull of the patient; the SP work station configured to perform surgical planning based on the pre-operative image and the intra-operative image; a lead having deep brain stimulation (DBS) electrodes on the lead, the DBS electrodes configured to be advanced to a target position proximate to or within the NBM area; an implantable pulse generator (IPG) coupled to the lead, the IPG configured to deliver DBS pulses through the DBS electrodes to the NBM, the implantable pulse generator configured to deliver DBS pulses for treating symptoms associated with Alzheimer'"'"'s Disease (AD); and wherein the surgical planning and advancing operations locate the DBS electrodes such that a Nucleus Accumbens (NAcc) and the NBM are both located within an energy trajectory of the DBS delivered by, and propagating from, the DBS electrodes. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18)
-
-
19. A method for performing deep brain stimulation (DBS) therapy, the method comprising:
-
pre-operatively acquiring at least one pre-operative image of a brain of a patient with at least one imaging sub-system; determining a location of a Nucleus Balsas of Meynert (NBM) for therapy in the at least one pm-operative image; intra-operatively acquiring at least one intra-operative image of the brain after obtaining an access opening through a skull of the patient; performing surgical planning based on the pre-operative image and the intra-operative image; advancing a lead having deep brain stimulation (DBS) electrodes to a target position proximate to or within the NBM area; coupling the lead to an implantable pulse generator (IPG) configured to deliver DBS pulses through the DBS electrodes to the NBM, the IPG to deliver DBS pulses for treating symptoms associated with Alzheimer'"'"'s Disease (AD); and delivering an NBM therapy utilizing a first combination of DBS electrodes to the NBM area, and delivering a Nucleus Accumbens (NAcc) therapy utilizing a second combination of DBS electrodes to a NAcc area, the first and second combination of DBS electrodes having at least one different electrode. - View Dependent Claims (20)
-
Specification