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Implantable neurostimulator-implemented method utilizing multi-modal stimulation parameters

  • US 9,999,773 B2
  • Filed: 10/22/2014
  • Issued: 06/19/2018
  • Est. Priority Date: 10/30/2013
  • Status: Active Grant
First Claim
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1. A medical device for vagus nerve stimulation, comprising:

  • an electrode assembly comprising a first pair of electrodes structured to be implanted on or near a vagus nerve and a second pair of electrodes structured to be implanted on or near the vagus nerve, wherein the first pair of electrodes is configured to be implanted closer to a brain of a patient than the second pair of electrodes, and the second pair of electrodes is configured to be implanted closer to a heart of the patient than the first pair of electrodes;

    a neurostimulator coupled to the electrode assembly, said neurostimulator adapted to deliver electrical stimulation to a patient; and

    a control system coupled to the neurostimulator, said control system being programmed to cause the neurostimulator to deliver, in a predetermined pattern, a first mode of stimulation by the first pair of electrodes and a second mode of stimulation by the second pair of electrodes, wherein the first mode of stimulation is configured to generate an afferent response in the vagus nerve comprising propagation of action potentials to the brain and the second mode of stimulation is configured to generate an efferent response in the vagus nerve comprising propagation of action potentials to the heart;

    wherein at least one of the first mode of stimulation or the second mode of stimulation comprises a stimulation frequency inclusively between 5 and 10 Hz; and

    wherein the predetermined pattern comprises delivery of the first mode of stimulation during a first time and delivery of the second mode of stimulation during a second time, wherein delivery of the first mode of stimulation is suspended during the second time and delivery of the second mode of stimulation is suspended during the first time.

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