Cartridges, kits, and methods for enhanced detection and quantification of analytes
First Claim
1. A sample analysis cartridge comprising a housing:
- an input tunnel that extends from an aperture in the housing, the input tunnel configured to permit insertion of a sample collection device having a distal portion adapted to be exposed to a sample;
a reservoir configured to hold a fluid, the reservoir further configured to receive the sample collected by the sample collection device;
a collet disposed in the input tunnel between the reservoir and the aperture, the collet comprising a collet body having a collet proximal end and a collet distal end, a deflector portion, and a lumen extending between the collet proximal end and the collet distal end, the lumen sized to receive the distal portion of the sample collection device therein;
a shuttle at least partially disposed within the collet in a first position, the shuttle comprising a shuttle body having a shuttle proximal end and a shuttle distal end and defining a sample compartment between the shuttle proximal end and the shuttle distal end, the shuttle configured to receive the sample collected by the sample collection device in the sample compartment through an opening at the shuttle proximal end, the shuttle further configured to move within the input tunnel from the first position to a second position responsive to force applied on the shuttle from the sample collection device during insertion of the sample collection device in the input tunnel; and
a contact switch disposed adjacent the deflector portion of the collet,wherein the deflector portion is configured to deflect to activate the contact switch responsive to force applied on the deflector portion by the sample collection device during insertion of the sample collection device in the input tunnel.
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Accused Products
Abstract
Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.
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Citations
28 Claims
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1. A sample analysis cartridge comprising a housing:
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an input tunnel that extends from an aperture in the housing, the input tunnel configured to permit insertion of a sample collection device having a distal portion adapted to be exposed to a sample; a reservoir configured to hold a fluid, the reservoir further configured to receive the sample collected by the sample collection device; a collet disposed in the input tunnel between the reservoir and the aperture, the collet comprising a collet body having a collet proximal end and a collet distal end, a deflector portion, and a lumen extending between the collet proximal end and the collet distal end, the lumen sized to receive the distal portion of the sample collection device therein; a shuttle at least partially disposed within the collet in a first position, the shuttle comprising a shuttle body having a shuttle proximal end and a shuttle distal end and defining a sample compartment between the shuttle proximal end and the shuttle distal end, the shuttle configured to receive the sample collected by the sample collection device in the sample compartment through an opening at the shuttle proximal end, the shuttle further configured to move within the input tunnel from the first position to a second position responsive to force applied on the shuttle from the sample collection device during insertion of the sample collection device in the input tunnel; and a contact switch disposed adjacent the deflector portion of the collet, wherein the deflector portion is configured to deflect to activate the contact switch responsive to force applied on the deflector portion by the sample collection device during insertion of the sample collection device in the input tunnel. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A sample analysis cartridge comprising a housing:
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an input tunnel that extends from an aperture in the housing, the input tunnel configured to permit insertion of a sample collection device having a distal portion adapted to be exposed to a sample; a reservoir configured to hold a fluid, the reservoir further configured to receive the sample collected by the sample collection device; a shuttle disposed in the input tunnel between the reservoir and the aperture in a first position, the shuttle comprising a shuttle body having a shuttle proximal end and a shuttle distal end and defining a sample compartment between the shuttle proximal end and the shuttle distal end, the shuttle configured to receive the sample collected by the sample collection device in the sample compartment through an opening at the shuttle proximal end, the shuttle further configured to move within the input tunnel from the first position to a second position responsive to force applied on the shuttle from the sample collection device during insertion of the sample collection device in the input tunnel; and a collet disposed in the input tunnel and coupled to the shuttle in the first position such that the shuttle is at least partially disposed within the collet in the first position, the collet comprising a collet body having a collet proximal end and a collet distal end and a lumen extending between the collet proximal end and the collet distal end, the lumen sized to receive the distal portion of the sample collection device therein, the collet configured to decouple from the shuttle during insertion of the sample collection device in the input tunnel, wherein the shuttle is configured to move within the input tunnel from the first position to the second position after the collet is decoupled from the shuttle such that the shuttle is at least partially disposed within the reservoir in the second position and the sample is exposed to the fluid in the reservoir. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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Specification