Dental restorative cement pastes

• US RE33,221 E
• Filed: 05/18/1987
• Issued: 05/22/1990
• Est. Priority Date: 04/29/1982
• Status: Expired due to Term

• Current Assignee: Stryker Technologies Corporation
• Original Assignee: American Dental Association Health Foundation
• Inventors: Chow, Laurence C., Brown, Walter E.
• Primary Examiner(s): Lieberman, Paul
• Assistant Examiner(s): THERKORN, LINDA SKALING
• Application Number:
  US07/051,739
• Time in Patent Office: 1,100 Days
• Field of Search: 106/35, 106/38.3, 106/85, 423/308, 423/311, 433/199.1, 433/201.1, 433/212.1, 433/226, 433/228.1, 433/215, 623/16 A, 623/16 B, 128/92 R, 128/92 YQ, 501/1
• US Class Current: 423/308
• CPC Class Codes: A61K 6/0008 by particle size
• CPC Class Codes: A61K 6/0085 Apatite
• CPC Class Codes: A61K 6/0643 Phosphate cements apatite A61K6/033
• CPC Class Codes: A61K 8/24 Phosphorous; Compounds thereof
• CPC Class Codes: A61L 24/02 containing inorganic materials
• CPC Class Codes: A61L 2430/12 for dental implants or prostheses
• CPC Class Codes: A61L 27/12 Phosphorus-containing materials, e.g. apatite
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Abstract

Compositions that are useful and unique as dental remineralizers and dental cements, as well as methods for their use, are disclosed. The compositions are mixtures of at least two sparingly soluble calcium phosphates that are present in excess and a dilute aqueous solution approximately saturated with

The invention described herein was made in the course of research partially supported by a grant from the National Institute of Dental Research.

Claims

1. A .[.dental restorative.]. paste .Iadd.consisting essentially of .Iaddend..[.comprising.]. an aqueous mixture of Ca₄ (PO₄)O and at least one other calcium phosphate selected from the group consisting of CaHPO₄.2H₂ O .[.,.]. .Iadd.and .Iaddend.CaHPO₄, .[.Ca₈ H₂ (PO₄)₆.5H₂ O, β

-Ca₃ (PO₄)₂, β

-Ca₃ (PO₄)₂, and modified Ca₃ (PO₄)₂, the paste being capable of hardening.]. .Iadd.which aqueous mixture hardens .Iaddend.into a cement .Iadd.at an ambient temperature.

2. The paste of claim 1 wherein the other calcium phosphate is CaHPO₄.2H₂ O.

3. The paste of claim 1 wherein the other calcium phosphate is CaHPO₄. .[.4. The paste of claim 1 wherein the other calcium phosphate is Ca₈ H₂ (PO₄)₆.5H₂ O..]. .[.5. The paste of claim 1 wherein

4. the other calcium phosphate is β

-Ca₃ (PO₄)₂..]. 6. The paste of claim 1 wherein both calcium phosphates are in crystalline,

5. cryptocrystalline, or amorphous form. 7. The paste of claim 1 further .[.comprising.]. .Iadd.including .Iaddend.up to approximately 10% by weight of additional calcium or phosphate containing compounds .Iadd.in an

8. PO₄. 10. The paste of claim 1 further .[.comprising.]. .Iadd.including .Iaddend.fluoride containing compounds such that the fluoride content of the paste is up to approximately 3.8% by weight .Iadd.in an amount sufficient to increase the rate of precipitation of

11. into a cement at an ambient temperature.Iaddend.. 13. The paste of claim 1 additionally .[.comprising.]. .Iadd.including .Iaddend.a seed crystal compound selected from the group consisting of hydroxyapatite and fluorapatite .Iadd.in an amount sufficient to reduce the setting time of the cement.Iaddend.. .Iadd.14. The paste of claim 13 wherein the seed crystal compound is hydroxyapatite, the hydroxyapatite being present in an amount up to 43% by weight and in an amount sufficient to reduce the setting time of the cement. .Iaddend. .Iadd.15. The paste of claim 1 additionally including up to approximately 5% by weight of a high molecular weight crystal growth inhibitor selected from the group consisting of proteoglycans, glycoproteins, polylysine and protamine in an amount sufficient to inhibit the growth of hydroxyapatite crystals. .Iaddend. .Iadd.16. The paste of claim 1 additionally including β

-Ca₃ (PO₄)₂ in an amount sufficient to achieve setting expansion of the cement. .Iaddend. .Iadd.17. The paste of claim 1 additionally including up to 1% by weight of a crystal habit modifier selected from the group consisting of Mg²⁺, Sr²⁺, citrate, phosphonates, carbonate, polyphosphates, sucrose phosphate, and phosphocitrate in an amount sufficient to achieve setting expansion of the

12. cement. .Iaddend. .Iadd.18. The paste of claim 1 wherein the paste is slightly acidic. .Iaddend. .Iadd.19. The paste of claim 1 where in the

13. paste is slightly basic. .Iaddend. .Iadd.20. The paste of claim 1 additionally including granular sugar, the sugar being present in an amount up to 20% by weight and in an amount sufficient to form a porous cement upon removal of the sugar by application of hot water to the cement. .Iaddend.

7. [.or.]. .Iadd.and .Iaddend.Ca(C₂ H₃ O₂)₂. 9. The paste of claim 7 wherein the additional phosphate containing compounds .[.comprise.]. .Iadd.are selected from the group consisting of .Iaddend.NaH₂ PO₄ .[.or.]. .Iadd.and .Iaddend.(NH₄)H₂

6. amount sufficient to alter the pH of the paste.Iaddend.. 8. The paste of claim 7 wherein the additional calcium containing compounds .[.comprise.]. .Iadd.are selected from the group consisting of .Iaddend.CaCl₂

10. SiF₆ .[.or.]. .Iadd.and .Iaddend.NaPO₃ F. 12. A paste .[.comprising.]. .Iadd.consisting essentially of .Iaddend.CaHPO₄ and Ca₄ (PO₄)₂ O having a particle size of approximately 1 μ

m and a 20mM solution of H₃ PO₄ .Iadd., the paste hardening

9. hydroxyapatite from the paste.Iaddend.. 11. The paste of claim 10 wherein the fluoride containing compounds .[.comprise.]. .Iadd.are selected from the group consisting of .Iaddend.CaF₂, SrF₂, NaF, Na₂