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Oral therapeutic system having systemic action

  • US RE34,990 E
  • Filed: 10/08/1993
  • Issued: 07/04/1995
  • Est. Priority Date: 08/07/1986
  • Status: Expired due to Term
First Claim
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1. An oral therapeutic system for administering carbamazepine comprising(a) a wall made of acylated cellulose which is permeable to water but impermeable to the components of the drug containing core and to the ions present in gastric or intestinal juices;

  • (b) a core containing finely particulate carbamazepine as a drug, hydroxypropylmethyl cellulose as protective colloid, a swellable hydrophilic polymer selected from the group consisting of poly-N-vinyl-2-pyrrolidone, polyvinyl alcohol, alkylene oxide homopolymers, methyl cellulose, ethyl cellulose, hydroxypropyl cellulose, the copolymer of vinylpyrrolidone and vinyl acetate, the mixture of the copolymer of vinylpyrrolidone and vinyl acetate and the homopolymer of ethylene oxide and, a water soluble compound for inducing osmosis; and

    (c) a passageway through the wall (a) for delivering the components present in the core to the environmental gastric or intestinal juices.

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