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Chemoprotective isothiocyanates

DC
  • US RE36,784 E
  • Filed: 05/02/1997
  • Issued: 07/18/2000
  • Est. Priority Date: 03/12/1993
  • Status: Expired due to Term
First Claim
Patent Images

1. A .[.pharmaceutical.]. composition comprising .[.an active ingredient which is.]. .Iadd.an analogue of .Iaddend.sulforaphane ((-)1-isothiocyanato-(4R)-(methylsulfinyl)butane) .[.(CAS 4478-93-7) or an analogue thereof.]., said analogue being selected from the group consisting of:

  • 6-isothiocyanato-2-hexanone .[.(GHP

         1105).].;

    exo-2-acetyl-6-isothiocyanatonorbornane .[.(GHP

         1066).].;

    exo-2-isothiocyanato-6-methylsulfonylnorbornane .[.(GHP

         1068).].;

    6-isothiocyanato-2-hexanol .[.(GHP 1106.].;

    1-isothiocyanato-4-dimethylphosphonylbutane .[.(GHP

         1078).].;

    exo-2-(1'"'"'-hydroxyethyl)-5-isothiocyanatonorbornane .[.(GHP

         1075).].;

    exo-2-acetyl-5-isothiocyanatonorbornane .[.(GHP

         1067).].;

    1-isothiocyanato-5-methylsulfonylpentane .[.(GHP

         1003).].; and

    cis- or trans-3-(methylsulfonyl)cyclohexylmethylisothiocyanate .[.(GHP 1079 or

         1080).].. .[.2. The pharmaceutical composition of claim 1 wherein said active ingredient is sulforaphane..]..[.3. The pharmaceutical composition of claim 1 wherein said active ingredient is selected from the group consisting of;

    6-isothiocyanato-2-hexanone (GHP

         1105);

    exo-2-acetyl-6-isothiocyanatonorbornane (GHP

         1066);

    exo-2-isothiocyanato-6-methylsulfonylnorbornane (GHP

         1068);

    6-isothiocyanato-2-hexanol (GHP

         1106);

    1-isothiocyanato-4-dimethylphosphonylbutane (GHP

         1078);

    exo-2-(1'"'"'-hydroxyethyl)-5-isothiocyanatonorbornane (GHP

         1075);

    exo-2-acetyl-5-isothiocyanatonorbornane (GHP

         1067);

    1-isothiocyanato-5-methylsulfonylpentane (GHP

         1003); and

    cis- or trans-3-(methylsulfonyl)cyclohexylmethylisothiocyanate (GHP 1079 or

         1080)..]..[.4. The pharmaceutical composition of claim 1 further

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