Extracorporeal whole body hyperthermia using alpha-stat regulation of blood pH and pCO2
First Claim
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1. A method of extracorporeal treatment of a patient, comprising the steps of:
- (a) cannulating a patient for extracorporeal blood circulation wherein a blood flow circuit is defined between a first point of cannulation and a second point of cannulation;
(b) then pumping a patient'"'"'s blood through the blood flow circuit;
(c) monitoring a patient'"'"'s temperature, blood pressure, and a flow rate of blood as the patient'"'"'s blood passes through the blood flow circuit;
(d) as the patient'"'"'s blood is monitored, heating the patient'"'"'s blood in the blood flow circuit to an elevated temperature;
then (e) measuring blood pH, partial pressure of CO2 gas in the patient'"'"'s blood (pCO2), and HCO3−
concentration in the patient'"'"'s blood;
(f) calculating a base excess from the pH, pCO2, and HCO3−
concentration of the patient'"'"'s blood measured in step (e); and
then (g) adjusting a respiratory rate of the patient and administration of a concentration of NaHCO3 in the patient'"'"'s blood as a function of at least one of a change in the blood pH, a change in the pCO2, and a change in the base excess.
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Abstract
A device and method for extracorporeal whole body hyperthermia treatment of a patient'"'"'s blood using alpha-stat regulation of blood pH and pCO2 is described. The respiratory rate of a patient is either increased or decreased in accordance with the changes in pH, pCO2, and base excess. The regulation of blood during the hyperthermic treatment of the patient'"'"'s blood stabilizes the biochemical reactions fundamental to the metabolic welfare of the organisms within the patient'"'"'s blood while the viruses within the patient'"'"'s blood are eliminated.
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18 Claims
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1. A method of extracorporeal treatment of a patient, comprising the steps of:
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(a) cannulating a patient for extracorporeal blood circulation wherein a blood flow circuit is defined between a first point of cannulation and a second point of cannulation;
(b) then pumping a patient'"'"'s blood through the blood flow circuit;
(c) monitoring a patient'"'"'s temperature, blood pressure, and a flow rate of blood as the patient'"'"'s blood passes through the blood flow circuit;
(d) as the patient'"'"'s blood is monitored, heating the patient'"'"'s blood in the blood flow circuit to an elevated temperature;
then(e) measuring blood pH, partial pressure of CO2 gas in the patient'"'"'s blood (pCO2), and HCO3−
concentration in the patient'"'"'s blood;
(f) calculating a base excess from the pH, pCO2, and HCO3−
concentration of the patient'"'"'s blood measured in step (e); and
then(g) adjusting a respiratory rate of the patient and administration of a concentration of NaHCO3 in the patient'"'"'s blood as a function of at least one of a change in the blood pH, a change in the pCO2, and a change in the base excess. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method of extracorporeal treatment of a patient comprising:
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(a) circulating the patient'"'"'s blood from the patient through an extracorporeal blood flow circuit, and back to the patient, wherein the blood returned to the patient has been heated within the blood flow circuit to an elevated temperature range;
(b) measuring blood pH, partial pressure of CO2 gas in the patient'"'"'s blood (pCO2), and HCO3−
concentration in the patient'"'"'s blood;
(c) calculating a base excess from the pH, pCO2, and HCO3−
concentration of the patient'"'"'s blood measured in step (b);
and(d) adjusting a respiratory rate of the patient and administration of a concentration of NaHCO3 in the patient'"'"'s blood as a function of at least one of a change in the blood pH, a change in the pCO2, and a change in the base excess. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18)
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Specification