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Methods for treating early morning pathologies

  • US RE39,239 E1
  • Filed: 09/17/2002
  • Issued: 08/15/2006
  • Est. Priority Date: 01/29/1997
  • Status: Expired due to Term
First Claim
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1. A method for treating an early morning pathology, said method comprising administering to a subject in need of treatment, a time-specific controlled release dosage formulation comprising consisting essentially of (1) a core including at least one pharmaceutically active agent effective for the treatment of said morning pathology, and (2) a an outer swellable and erodible polymeric coating layer substantially surrounding said core;

  • wherein said formulation is administered prior to sleep, and wherein said swellable polymeric coating layer delays the release of said pharmaceutically active agent from said core for a predetermined period of time dependent upon the thickness of said swellable polymeric coating layer, to permit delivery of said pharmaceutically active agent at about the time of awakening and to treat said early morning pathology.

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