Metabolic intervention with GLP-1 or its biologically active analogues to improve the function of the ischemic and reperfused brain
First Claim
1. A method of increasing insulinotropic response in ischemia treating reperfusion-injured brain cells after an ischemic event comprising administering a composition containing glucagon-like peptide-1 (GLP-1) and a pharmaceutical carrier for a time sufficient and under conditions effective to increase insulinotropic response which produces insulin, with the produced insulin being neuroprotective by direct neurotropic effects and by controlling stroke-related hyperglycemia treat reperfusion injury.
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Accused Products
Abstract
It has now been discovered that GLP-1 treatment after acute stroke or hemorrhage, preferably intravenous administration, can be an ideal treatment because it provides a means for optimizing insulin secretion, increasing brain anabolism, enhancing insulin effectiveness by suppressing glucagon, and maintaining euglycemia or mild hypoglycemia with no risk of severe hypoglycemia.
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Citations
29 Claims
- 1. A method of increasing insulinotropic response in ischemia treating reperfusion-injured brain cells after an ischemic event comprising administering a composition containing glucagon-like peptide-1 (GLP-1) and a pharmaceutical carrier for a time sufficient and under conditions effective to increase insulinotropic response which produces insulin, with the produced insulin being neuroprotective by direct neurotropic effects and by controlling stroke-related hyperglycemia treat reperfusion injury.
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10. A method of increasing insulinotropic response in ischemia injured brain cells comprising administering to an individual in need of such treatment a dose of 0.1 pmol/kg/min to 10 pmol/kg/min of a composition containing glucagon-like peptide-1 (GLP-1) and a pharmaceutical carrier for a time sufficient and under conditions effective to increase insulinotropic response which produces insulin, with the produced insulin being neuroprotective by direct neurotropic effects and by controlling stroke-related hyperglycemia.
- 12. A method of treating or ameliorating injury to brain cells in a subject following reperfusion after a period of ischemia comprising administering a composition comprising a glucagon-like peptide-1 (GLP-1) mimetic and a pharmaceutical carrier for a time sufficient and under conditions effective to treat or ameliorate said injury.
- 18. A method of treating or ameliorating reperfusion injury to brain cells following stroke in a subject in need thereof, comprising administering a composition comprising an exendin to said subject for a time sufficient and under conditions effective to treat or ameliorate the reperfusion injury.
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26. A method of treating or ameliorating injury to brain cells in a subject following a period of ischemia comprising administering a composition comprising an exendin and a pharmaceutical carrier.
- 27. The method of claim 27 wherein said exendin is exendin-4.
Specification