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Multi-tier method of developing localized calibration models for non-invasive blood analyte prediction

  • US RE41,333 E1
  • Filed: 01/27/2005
  • Issued: 05/11/2010
  • Est. Priority Date: 07/22/1999
  • Status: Expired due to Term
First Claim
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1. A method of developing a multi-tiered calibration model for estimating concentration of a target blood analyte from measured tissue spectra, comprising the steps of:

  • providing a calibration set, wherein said calibration set comprises a data set of exemplar spectral measurements from a representative sampling of a subject population;

    initially, classifying said exemplar measurements into previously defined classes based on a priori a priori information pertaining to a corresponding subject;

    further classifying said exemplar measurements into previously defined classes based on at least one instrumental measurement at a tissue measurement site;

    extracting at least one feature from said exemplar measurements for still further classification, wherein a decision rule makes class assignments; and

    calculating at least one localized calibration model based on said classified measurements and an associated set of reference values.

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