Single-arc dose painting for precision radiation therapy
First Claim
1. A method for designing a radiation treatment for a subject using single arc dose painting, comprising:
- providing an unconstrained optimization map which supplies intensity profiles of densely-spaced radiation beams;
aligning each intensity profile to a pair of multiple leaf collimation (MLC) leaves;
applying a shortest path algorithm to convert each pair of MLC leaves to a set of leaf aperture sequences, said set of leaf aperture sequences forming a shortest path single arc thereof;
andconnecting each single arc of leaf apertures to form a final treatment single arc path, thereby designing the single arc dose painting radiation treatment; and
delivering a treatment dose of radiation to the subject during a single rotation along one or more of the final treatment single arc path.
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Accused Products
Abstract
Provided herein are methods and systems for designing a radiation treatment for a subject using single arc dose painting. The methods and systems comprise an algorithm or a computer-readable product having the same, to plan the radiation treatment. The algorithm converts pairs of multiple leaf collimation (MLC) leaves to sets of leaf aperture sequences that form a shortest path single arc thereof where the pairs of MLC leaves each aligned to an intensity profile of densely-spaced radiation beams, and connects each single arc of leaf apertures to form a final treatment single arc. Also provided is a method for irradiating a tumor in a subject using single arc dose painting.
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Citations
48 Claims
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1. A method for designing a radiation treatment for a subject using single arc dose painting, comprising:
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providing an unconstrained optimization map which supplies intensity profiles of densely-spaced radiation beams; aligning each intensity profile to a pair of multiple leaf collimation (MLC) leaves; applying a shortest path algorithm to convert each pair of MLC leaves to a set of leaf aperture sequences, said set of leaf aperture sequences forming a shortest path single arc thereof;
andconnecting each single arc of leaf apertures to form a final treatment single arc path, thereby designing the single arc dose painting radiation treatment; and delivering a treatment dose of radiation to the subject during a single rotation along one or more of the final treatment single arc path. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A system for delivering radiation treatment using single arc dose painting, comprising in a radiation delivery device:
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a radiation source for generating a radiation beam; a multiple leaf collimator having a plurality of leafs for shaping the a radiation beam; structure for generating tangibly storing an algorithm enabling processor-executable instructions to generate an unconstrained optimization map of intensity profiles of densely-spaced radiation beams; structure for aligning tangibly storing an algorithm enabling processor-executable instructions to align each intensity profile to a pair of multiple leaf collimation (MLC) leaves;
andstructure for applying tangibly storing a shortest path algorithm, said shortest path algorithm converting enabling processor-executable instructions to convert each pair of MLC leaves to a set of leaf aperture sequences forming a shortest path single arc thereof, said shortest path algorithm and to further connecting connect each single arc of leaf apertures to form a final treatment single arc effective for single arc dose painting; and a source of a dose of continuous radiation beams, varying radiation beams or both deliverable to the subject through each aperture during a single rotation along the final treatment single arc path. - View Dependent Claims (15, 16, 17)
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18. A computer-readable medium tangibly storing an algorithm to determine a final single arc path for a single arc dose painting radiation treatment, said algorithm enabling processor-executable instructions to:
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convert pairs of multiple leaf collimation (MLC) leaves to sets of leaf aperture sequences that form a shortest path single arc thereof, said pairs of MLC leaves each aligned to an intensity profile of densely-spaced radiation beams; and connect each single arc of leaf apertures to form a final treatment single arc. - View Dependent Claims (19, 20)
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21. A method for designing a radiation treatment using a treatment arc comprising:
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accessing an optimization map that supplies intensity profiles wherein at least some of the intensity profiles differ from one another with respect to a plurality of radiation beams; aligning specific ones of the intensity profiles to corresponding pairs of multiple leaf collimator (MLC) leaves; determining via a shortest path algorithm, for at least one of the pairs of MLC leaves, a plurality of leaf aperture sequences corresponding to angular intervals as each comprise a part of the treatment arc and combining the plurality of leaf aperture sequences over the angular intervals to form a treatment arc; developing a final treatment arc using the treatment arc; and delivering a dose of radiation to a subject based upon the leaf aperture sequences while traversing the final treatment arc;
wherein the dose of radiation comprises a continuous dose of radiation, a varying dose of radiation or both while traversing the final treatment arc. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28)
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29. A method for designing a radiation treatment comprising:
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accessing an optimization map that supplies intensity profiles wherein at least some of the intensity profiles differ from one another with respect to a plurality of radiation beams; using the intensity profiles to develop a plurality of multiple leaf collimator aperture settings for use at various angles along a treatment arc; determining via a shortest path algorithm a plurality of leaf aperture sequences from the plurality of multiple leaf collimator aperture settings; using the plurality of leaf aperture sequences to form a radiation treatment plan to deliver a dose of radiation to a subject while dynamically adjusting a corresponding leaf collimator aperture based upon the plurality of leaf aperture sequences while traversing the treatment arc; and delivering a dose of radiation to the subject while traversing the treatment arc using the radiation treatment plan;
wherein the dose of radiation comprises a continuous dose of radiation, a varying dose of radiation or both while traversing the treatment arc via the radiation treatment plan. - View Dependent Claims (30, 31)
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32. A method for designing a radiation treatment using a treatment arc comprising:
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accessing an optimization map that supplies intensity profiles wherein at least some of the intensity profiles differ from one another with respect to a plurality of radiation beams; determining via a shortest path algorithm a plurality of multiple leaf collimator aperture sequences corresponding to angular intervals as each comprise a part of the treatment arc and forming the treatment arc based at least in part on the plurality of leaf aperture sequences over the angular intervals to form a treatment arc that provides for sweeping a multiple leaf collimator aperture back and forth along a treatment arc; and delivering a dose of radiation to a subject while sweeping the multiple leaf collimator aperture back and forth along the treatment arc;
wherein the dose of radiation comprises a continuous dose of radiation, a varying dose of radiation or both along the treatment arc during delivery. - View Dependent Claims (33, 34)
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35. A planning system for developing a radiation treatment to be administered via a radiation source for generating a plurality of radiation beams and a multiple leaf collimator having a plurality of leafs for shaping the radiation beams, the planning system comprising:
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structure tangibly storing an algorithm enabling processor-executed instructions to access an optimization map that supplies intensity profiles wherein at least some of the intensity profiles differ from one another with respect to the plurality of radiation beams; structure tangibly storing an algorithm enabling processor-executed instructions to align specific ones of the intensity profiles to corresponding pairs of multiple leaf collimator (MLC) leaves; structure tangibly storing a shortest path algorithm enabling processor-executed instructions to; determine, for at least one of the pairs of MLC leaves, a plurality of leaf aperture sequences corresponding to angular intervals as each comprise a part of the treatment arc; combine the plurality of leaf aperture sequences over the angular intervals to form a treatment arc; and develop a final treatment arc using the treatment arc; a source of a continuous dose of radiation deliverable to a subject based upon the leaf aperture sequences while traversing the single treatment arc; and a source of a varying dose of radiation deliverable to a subject based upon the leaf aperture sequences while traversing the single treatment arc. - View Dependent Claims (36, 37, 38, 39, 40, 41, 42)
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43. A planning system for developing a radiation treatment to be administered via a radiation source for generating a plurality of radiation beams and a multiple leaf collimator having a plurality of leafs for shaping the radiation beams, the planning system comprising:
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structure tangibly storing an algorithm enabling processor-executed instructions to access an optimization map that supplies intensity profiles wherein at least some of the intensity profiles differ from one another with respect to a plurality of radiation beams; structure tangibly storing an algorithm enabling processor-executed instructions to use the intensity profiles to develop a plurality of multiple leaf collimator aperture settings for use at various angles along a treatment arc; structure tangibly storing a shortest path algorithm enabling processor-executed instructions to determine a plurality of leaf aperture sequences using the plurality of multiple leaf collimator aperture settings and to use the plurality of leaf aperture sequences to form a radiation treatment plan to deliver a dose of radiation to a subject while dynamically adjusting a corresponding leaf collimator aperture based upon the plurality of leaf aperture sequences while traversing the single treatment arc; and a source of a continuous dose of radiation, a varying dose of radiation or both deliverable to the subject while traversing the single treatment arc. - View Dependent Claims (44, 45)
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46. A planning system for developing a radiation treatment to be administered via a radiation source for generating a plurality of radiation beams and a multiple leaf collimator having a plurality of leafs for shaping the radiation beams, the planning system comprising:
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structure tangibly storing an algorithm enabling processor-executed instructions to access an optimization map that supplies intensity profiles wherein at least some of the intensity profiles differ from one another with respect to a plurality of radiation beams; structure tangibly storing a shortest path algorithm enabling processor-executed instructions to; determine a plurality of multiple leaf collimator aperture sequences corresponding to angular intervals as each comprise a part of the treatment arc; and form the treatment arc based at least in part on the plurality of leaf aperture sequences over the angular intervals to form a treatment arc that provides for sweeping a multiple leaf collimator aperture back and forth along the treatment arc; and a source of a continuous dose of radiation, a varying dose of radiation or both deliverable to a subject while sweeping the multiple leaf collimator aperture back and forth along the treatment arc. - View Dependent Claims (47, 48)
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Specification