Compounds and methods for treating inflammatory and fibrotic disorders
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Accused Products
Abstract
Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of the p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the p38 MAPK by the compound. Also disclosed are derivatives and analogs of pirfenidone, useful for modulating a stress activated protein kinase (SAPK) system.
Mederski et al., Tetrahedron (1999), 55(44), 12757-12770.*
Azuma et al., “A placebo control and double blind phase II clinical study of pirfenidone in patients with idiopathic pulmonary fibrosis in Japan”, Am J Respir Crit Care Med., 165:A729 (2002).
Badger, et al., “Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function”, J. Pharmacol. Exp. Ther. 279:1453-61 (1996).
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Citations
19 Claims
- 1. A compound of formula II (II)
- 3. A compound having a structure of formula (III) or formula (IV)
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17. A compound selected from the group consisting of:
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19. A compound selected from the group consisting of:
Specification