Glue composition for lung volume reduction
First Claim
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1. A method of reducing lung volume in a lung of a subject in need thereof, comprising:
- administering an effective amount of a glue composition to a localized region of damaged lung tissue of the subject, wherein the glue composition comprises a polyvinylalcohol polymer and a cross-linker, such that the polymer and cross-linker form a hydrogel in the lung, thereby reducing lung volume in the lung of the subject.
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Abstract
The present invention relates to methods and compositions for sealing localized regions of damaged lung tissue to reduce overall lung volume. The glue compositions provide a glue featuring an adhering moiety coupled to one or more other moieties including, for example, a cross-linkable moiety and/or one other adhering moiety. The methods and compositions of the invention find use, for example, in treating pulmonary conditions, such as emphysema.
158 Citations
40 Claims
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1. A method of reducing lung volume in a lung of a subject in need thereof, comprising:
administering an effective amount of a glue composition to a localized region of damaged lung tissue of the subject, wherein the glue composition comprises a polyvinylalcohol polymer and a cross-linker, such that the polymer and cross-linker form a hydrogel in the lung, thereby reducing lung volume in the lung of the subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method of reducing lung volume in a lung of a subject in need thereof comprising:
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providing a glue composition comprising a cross-linkable moiety and a polyvinylalcohol; administering said glue composition to a localized region of the lung tissue of the subject; and cross-linking said cross-linkable moiety and said polyvinylalcohol to form a hydrogel, thereby reducing lung volume. - View Dependent Claims (19, 20)
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21. A glue composition comprising:
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a polymer; a cross-linker, such that the polymer and cross-linker form a hydrogel; and a sclerosing agent. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28)
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29. A glue composition comprising:
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a cross-linkable moiety; and a polyalcohol, such that said cross-linkable moiety and said polyalcohol form a hydrogel; and a sclerosing agent. - View Dependent Claims (30)
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31. A system for reducing lung volume in a lung of a patient, the system comprising:
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a delivery catheter advanceable through a bronchoscope in an airway of the lung of the patient to a localized treatment site of damaged lung tissue; and a glue composition injectable through the delivery catheter to the localized treatment site, wherein the glue composition comprises a polyvinylalcohol polymer and a cross-linker, such that the polymer and cross-linker form a hydrogel in the lung upon administration, thereby reducing lung volume in the lung of the patient. - View Dependent Claims (32, 33, 34, 35, 36, 37, 38, 39, 40)
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Specification