Calibration of sensors or measuring systems
First Claim
1. A measuring system for determining a value of a glucose concentration, the measuring system comprising:
- a. a measuring sensor (2, Rm, Rref), having a known gradient and a known offset, for recording a measured value in vivo in a temporally sequential or continuous fashion, and outputting measuring sensor values (P1, P2), the measured values of the measured variable or formed from the measured values, andb. a data acquisition device that receives the measuring sensor values and at least one reference value and forms characteristic values of the glucose concentration from the measuring sensor values, wherein the measuring sensor is a glycose sensor and the at least one reference value is a long-term glycose value, and wherein the data acquisition device creates a long-term glucose value from the at least one reference value and calculates a daily mean or a multiple daily mean of the glucose concentration from the measuring sensor values, and the offset is corrected in accordance with the result of the comparison of the daily mean or multiple daily mean with the long-term glucose value to minimize the difference between the daily mean or multiple daily mean and the long-term glucose value; and
whereinc. for the purpose of an automatic self-calibration of the measuring system, the data acquisition device compares the at least one reference value or a value calculated therefrom with the characteristic value from the corresponding time interval, and the offset of the measuring sensor is adjusted in accordance with the result of the comparison by a one-point calibration.
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Abstract
A method for adjusting a sensor, continuous sensor or automatic measuring system in an interstitium including the steps of adjusting the steepness of a measuring curve and a standard offset (standard axis intercept) prior to the use of the sensor, continuous sensor or measuring system, and adapting the offset by a point calibration by using a reference measure or value during the use. The present invention encompasses sensors, continuous sensors or automatic measuring systems calibrated or adjusted in accordance with the method, and in some embodiments, the offset adjusted prior to use is rectified according to the difference between a value determined by the sensor, continuous sensor or measuring system taking into account the standard steepness and the reference value.
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Citations
14 Claims
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1. A measuring system for determining a value of a glucose concentration, the measuring system comprising:
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a. a measuring sensor (2, Rm, Rref), having a known gradient and a known offset, for recording a measured value in vivo in a temporally sequential or continuous fashion, and outputting measuring sensor values (P1, P2), the measured values of the measured variable or formed from the measured values, and b. a data acquisition device that receives the measuring sensor values and at least one reference value and forms characteristic values of the glucose concentration from the measuring sensor values, wherein the measuring sensor is a glycose sensor and the at least one reference value is a long-term glycose value, and wherein the data acquisition device creates a long-term glucose value from the at least one reference value and calculates a daily mean or a multiple daily mean of the glucose concentration from the measuring sensor values, and the offset is corrected in accordance with the result of the comparison of the daily mean or multiple daily mean with the long-term glucose value to minimize the difference between the daily mean or multiple daily mean and the long-term glucose value; and
whereinc. for the purpose of an automatic self-calibration of the measuring system, the data acquisition device compares the at least one reference value or a value calculated therefrom with the characteristic value from the corresponding time interval, and the offset of the measuring sensor is adjusted in accordance with the result of the comparison by a one-point calibration. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A measuring system for determining a value of a glucose concentration, the measuring system comprising:
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a. a measuring sensor (2, Rm, Rref), having a known gradient and a known offset, for recording a measured value in vivo in a temporally sequential or continuous fashion, and outputting measuring sensor values (P1, P2), the measured values of the measured variable or formed from the measured values, wherein the measuring sensor is a viscosimetric affinity sensor, and b. a data acquisition device that receives the measuring sensor values and at least one reference value and forms characteristic values of the glucose concentration from the measuring sensor values, wherein the measuring sensor is a glycose sensor and the at least one reference value is a long-term glycose value, and wherein the data acquisition device creates a long-term glucose value from the at least one reference value and calculates a daily mean or a multiple daily mean of the glucose concentration from the measuring sensor values, and the offset is corrected in accordance with the result of the comparison of the daily mean or multiple daily mean with the long-term glucose value to minimize the difference between the daily mean or multiple daily mean and the long-term glucose value; and
whereinc. for the purpose of an automatic self-calibration of the measuring system, the data acquisition device compares one of the characteristic values with the at least one reference value or a value calculated therefrom with the characteristic value from the corresponding time interval, and the offset of the measuring sensor is adjusted in accordance with the result of the comparison by a one-point calibration.
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Specification